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| An Analysis of the Correlation Between the Levels of Peripheral Blood Ghrelin PTX3 TNF-α IL-6 and Myocardial Injury in Patients with Obstructive Sleep Apnea Syndrome |
| YANG Yanqiong, LUO Mei, LEI Qing, et al |
| Jianyang People's Hospital, Szechwan Jianyang 641400,China |
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Abstract Objective: To study the correlation between peripheral blood ghrelin, PTX3, TNF-α, IL-6 levels and myocardial injury in patients with obstructive sleep apnea syndrome. Methods: A prospective selection of 88 patients with OSAHS who were diagnosed and treated in our hospital from June 2018 to June 2020 were divided into mild group (5<AHI≤15) with 33 cases according to the apnea index detected by polysomnography. There were 31 cases in the moderate group (15<AHI≤30), 24 cases in the severe group (AHI>30), and 30 healthy persons (AHI≤5) in the same period in the healthy group for control. Peripheral blood ghrelin, PTX3, TNF-α, IL-6 levels and myocardial injury markers NT-proBNP, HFABP, cTnI levels were detected and compared in each group. Pearson test was used to analyze the correlation of the above indicators. Results: The levels of ghrelin, PTX3, TNF-α, and IL-6 in each group of OSAHS patients were significantly higher than those in the healthy group, and the levels of ghrelin, PTX3, TNF-α, and IL-6 followed the order of mild, moderate, and severe increasingly (P<0.001). The levels of NT-proBNP, HFABP, and cTnI in each group of OSAHS patients were significantly higher than those in the healthy group, and the levels of NT-proBNP, HFABP, and cTnI increased in the order of the mild group, moderate group, and severe group (P<0.001). OSAHS patients' ghrelin level was negatively correlated with NT-proBNP, HFABP, cTnI levels (r=-0.384, r=-0.653, r=-0.498; P<0.001); OSAHS patients' PTX3 level was correlated with NT-proBNP, HFABP, cTnI. The level was positively correlated (r=0.892, r=0.740, r=0.823; P<0.001); the level of TNF-α in OSAHS patients was positively correlated with the levels of NT-proBNP, HFABP, and cTnI (r=0.680, r=0.657, r =0.760; P<0.001) IL-6 levels in OSAHS patients were positively correlated with NT-proBNP, HFABP, and cTnI levels (r=0.674, r=0.666, r=0.778; P<0.001). Conclusion: The levels of ghrelin, PTX3, TNF-α, and IL-6 are importantly related to myocardial damage, which may be caused by the inflammatory reaction caused by impaired breathing and intermittent hypoxia, which may damage the cardiovascular system. Therefore, attention should be paid in the treatment of OSAHS to monitoring the level of inflammatory factors.
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2021, Vol. 27 
