|
|
|
| Diagnostic Value of Antithrombin-III Coagulation Index and D-Dimer in Different Degrees of Pregnancy-Induced Hypertension |
| CAI Congying |
| Huludao Central Hospital, Liaoning Huludao 125001, China |
|
|
|
|
Abstract Objective: To study the predictive value of antithrombin-III (AT-Ⅲ) coagulation index and D-dimer (D-D) in different degrees of pregnancy-induced hypertension. Methods: A total of 108 patients with pregnancy-induced hypertension admitted to our hospital from December 2017 to December 2019 were retrospectively analyzed. They were sub-grouped as pregnancy-induced hypertension group(42 cases), mild PE group (36 cases) and severe PE group (30cases) according to the severity of the disease. Another selection of normal pregnancy women during the same period were made the normal group (48 cases). The differences of four coagulation, AT-Ⅲ and D-D between each group were compared, and the correlation between each index and disease severity was analyzed. The working characteristic curve (ROC curve) was used to analyze the predictive value of the above indexes on the severity of the disease. Results: PT、APTT、TT and AT-Ⅲ levels of normal group> pregnancy-induced hypertension grouP> mild PE group and severe PE group, the values were statistically significant (Pall<0.05);The FIB、D-D level of normal grouP< pregnancy-induced hypertension grouP< mild PE group and severe PE group, the values were statistically significant (Pall<0.05).Spearman correlation analysis shows that PT, APTT, TT, and the AT-Ⅲ were significant negative correlated with PE (r= -0.790, -0.680,- 0.826, -0.597, Pall<0.05), FIB and D-D were positively correlated with PE (r =0.690, 0.780, Pall<0.05).ROC curve analysis showed that PT, APTT, TT, FIB, the AT-Ⅲ and D-D to predict severe PE AUC were 0.934, 0.930, 0.912, 0.874, 0.805, 0.867, predictive value is better . Conclusion: The coagulation condition of patients with different degrees of pregnancy-induced hypertension can be better reflected by four coagulations, AT-Ⅲ and D-D, and the predictive value of severe PE is high. By monitoring the above indexes, the severity of the disease can be detected as soon as possible, and the symptomatic treatment can be given.
|
|
|
|
|
|
[1] 王飞.妊娠期高血压孕妇血中α1-MG、CRP、D-D变化的临床意义[J].中国计划生育学杂志,2018,26(4):283~285.
[2] 陈婵.妊娠期高血压疾病的妊娠结局与血小板、凝血功能的相关性研究[J].血栓与止血学,2018,24(3):479~480,485.
[3] Jyotsna,Suri,Jagdish,et al.The impact of sleep-disordered breathing on severity of pregnancy-induced hypertension and feto-maternal outcomes.[J].Journal of Obstetrics and Gynaecology of India,2019,69(2):111~121.
[4] 索明莉,孙艳飞,杨海澜,等.妊娠期血浆D-二聚体及凝血四项监测的临床意义[J].甘肃科学学报,2019,31(6):40~43.
[5] 中华医学会妇产科学分会妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南(2015)[J].中华妇产科杂志,2015,50(10):721~728.
[6] 赵一梅,刘海燕,刘莹莹,等.妊娠高血压患者血浆D-二聚体、凝血指标表达水平及临床意义[J].临床军医杂志,2019,47(8):875~876.
[7] 杨介梅,王模奎.妊娠期高血压疾病母亲所娩新生儿凝血功能变化及临床意义[J].儿科药学杂志,2019,25(3):1~4.
[8] 徐晓燕,李晓红,郗爱喜,等.凝血功能和D-二聚体与妊娠高血压疾病严重程度的相关性[J].河北医学,2017,23(6):997~999.
[9] 崔照领,李扬,朱芳,等.妊娠期高血压疾病对新生儿凝血功能、NSE及PCT水平的影响[J].河北医科大学学报,2020,41(3):306~310.
[10] 黄田苗,黄丽漫.孕妇妊娠不同时期血浆D-二聚体和凝血四项变化及其检验价值分析[J].临床检验杂志(电子版),2019,8(3):167~168.
[11] 梁骑,邓健康,郭晓兰,等.妊娠不同时期孕妇血浆凝血四项、FDP、D-二聚体和AT-Ⅲ的变化及临床意义[J].中国临床研究,2019,32(1):75~77. |
|
|
|
2021, Vol. 27 
