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| Effects of Colloidal Bismuth Pectin Combined with Aluminum Phosphate Gel on Serum GAS ET IL-6 and IL-12 in Patients with Chronic Atrophic Gastritis |
| WU Danna, CHEN Chaocong, YU Huajun, et al |
| Danzhou People's Hospital, Hainan Danzhou 571700, China |
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Abstract Objective: To explore effects of colloidal bismuth pectin (CBP) combined with aluminum phosphate gel (APG) on serum gastrin (GAS), endothelin (ET), interleukin-6 (IL-6) and interleukin-12 (IL-12) in patients with chronic atrophic gastritis (CAG). Methods: 164 CAG admitted to the hospital from February 2017 to February 2020 were enrolled as study objects. They were divided into observation group and control group by simple random method, 41 cases in each group. The control group was treated with amoxicillin and CBP. On this basis, observation group was treated with APG. After treatment, negative conversion ratio of Helicobacter pylori (Hp), pathological scores, levels of serum GAS, ET, IL-6 and IL-12 were compared between the two groups. The curative effect and safety were evaluated. Results: ①The total response rates of treatment and negative conversion ratios of Hp in observation group and control group were (86.75%, 75.31%) and (69.88%, 59.26%), respectively. There was no significant difference between the groups (P>0.05). ②After treatment, pathological scores such as gastric atrophy, dysplasia, intestinal metaplasia, chronic inflammation and activity in both groups were significantly decreased (P<0.05). After treatment, pathological scores such as atrophy, chronic inflammation and activity in observation group were lower than those in control group (P<0.05). ③After treatment, GAS and IL-12 in both groups were increased, while ET and IL-6 were decreased (P<0.05). The increase or decrease amplitude of each index in observation group was significantly higher than that in control group (P<0.05). ④There was no significant difference in incidence of adverse reactions between the two groups (P>0.05). Conclusion: Pectin bismuth combined with Aluminium Phosphate Gel can improve the inflammatory state and gastric mucosal function in patients with chronic atrophic gastritis.
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2021, Vol. 27 
