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| Changes and Clinical Significance of Serum Adrenocorticotropic Hormone, Cortisol, Atrial Natriuretic Peptide and Interleukin-6 Levels Before and After Pediatric Nephroblastoma Surgery |
| HUANG Qingchen, QI Boxiang, et al |
| Xuzhou Children's Hospital, Jiangsu Xuzhou 221000, China |
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Abstract Objective: To explore the changes and clinical significance of serum adrenocorticotropic hormone (ACTH), cortisol (Cor), atrial natriuretic peptide (ANP) and interleukin-6 (IL-6) levels before and after pediatric nephroblastoma surgery. Methods: A total of 113 children undergoing pediatric nephroblastoma surgery who were admitted from February 2016 to August 2020 were enrolled. According to presence or absence of postoperative surgical stress response and complications, they were divided into poor prognosis group (32 cases) and good prognosis group (81 cases). The levels of serum ACTH, Cor, ANP and IL-6 in both groups before surgery, at 1d, 2d and 3d after surgery were detected. Results: The levels of serum ACTH, Cor, ANP and IL-6 at 1d, 2d and 3d after surgery were higher than those before surgery in both groups (P<0.05), which showed increased trend in poor prognosis group (P<0.05), while showed decreased trend in good prognosis group (P<0.05). At 1d, 2d and 3d after surgery, levels of serum ACTH, Cor, ANP and IL-6 in poor prognosis group were higher than those in good prognosis group (P<0.05). Conclusion: Monitoring ACTH, Cor, ANP and IL-6 after pediatric nephroblastoma surgery is beneficial to determine surgical stress degree. Continuously high levels of ACTH, Cor, ANP and IL-6 may indicate poor prognosis.
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2021, Vol. 27 
