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| Levels of Serum P-Selectin and VWF in Elderly Patients with Acute Pancreatitis and Their Relationship with Prognosis |
| HUANG Xiangmei, LI Jun, WANG Xuejiao, et al |
| The First Affiliated Hospital of Hainan Medical College, Hainan Haikou 5701022, China |
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Abstract Objective: To explore the levels of serum P-selectin and vWF in elderly patients with acute pancreatitis (AP) and their relationship with prognosis. Methods: A total of 159 AP patients who were treated in the hospital from June 2016 to June 2019 were enrolled as study group, while another 58 healthy controls during the same period were enrolled as control group. The levels of serum P-selectin and vWF were measured and compared between the two groups. The differences in P-selectin and vWF levels were compared among AP patients with different severity and prognosis. The single factors and independent risk factors that affected prognosis of AP patients were explored. The value of P-selectin, vWF and their combination in predicting prognosis of AP was explored. Results: Compared with control group, levels of serum P-selectin and vWF were significantly increased in study group (P<0.05). With the exacerbation of AP, levels of serum P-selectin and vWF were significantly increased (P<0.05). Compared with survival group, levels of serum P-selectin and vWF were significantly increased in death group (P<0.05). ROC curve analysis showed that AUC of P-selectin combined with vWF for predicting prognosis was significantly higher than that of P-selectin and vWF alone (0.935 vs 0.841, 0.833) (P<0.05). The results of univariate analysis on 28d survival rate of AP patients showed that there were certain effects of drinking history, cholelithiasis, scores of RANSON and BISAP, AP severity, P-selectin and vWF on 28d survival rate of AP patients (P<0.05). The results of Logistic multivariate analysis showed that drinking, cholelithiasis, RASON score not lower than 3 points, BISAP score not lower than 3 points, SAP, P-selection VWF not lower than 64.31μg/mL and vWF not lower than 231.68% were all independent risk factors affecting the 28d survival rate of AP patients (P<0.05). Conclusion: The levels of serum P-selectin and vWF in elderly AP patients are significantly increased, which are closely related to their prognosis. The combination of the two is of good clinical application value in predicting prognosis of AP patients.
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2021, Vol. 27 
