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| Glucocorticoid Combined with Bronchoalveolar Lavage Fluid on Children with Lobar Pneumonia and Its Influences on Plasma T Lymphocytes Immunoglobulins and Inflammatory Factors |
| TANG Yafei, JI Kaituo, MA Yong |
| The Second People's Hospital of Anhui Province, Anhui Hefei 230032, China |
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Abstract Objective: To explore the curative effect of glucocorticoid combined with bronchoalveolar lavage fluid (BALF) on children with lobar pneumonia and its influences on plasma T lymphocytes, immunoglobulins and inflammatory factors. Methods: A total of 158 children with lobar pneumonia who were admitted to the hospital from October 2018 to October 2019 were enrolled and divided into observation group (n=83) and control group (n=75) by simple random grouping method. The control group was treated with glucocorticoid, while observation group was treated with glucocorticoid and BALF. The clinical curative effect, improvement of clinical symptoms and signs, levels of plasma T lymphocytes, immunoglobulins and inflammatory factors before and after treatment were compared between the two groups. Results: The total response rate of treatment in observation group was higher than that in control group (92.77% vs 78.67%) (P<0.05). The relief time of cough, fading time of hyperpyrexia, disappearance time of lung shadows and lung rales in observation group were shorter than those in control group (P<0.05). After treatment, CD3+ and CD4+ levels in observation group were higher than those in control group, while CD8+ level was lower than that in control group (P<0.05). After treatment, levels of immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) in observation group were higher than those in control group, while levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were lower than those in control group (P<0.05). Conclusion: The curative effect of glucocorticoid combined with BALF is significant on children with lobar pneumonia, which can effectively relieve clinical symptoms, improve immune function, reduce inflammatory response and promote their recovery.
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2021, Vol. 27 
