稳定型冠心病合并肥胖患者血清Ghrelin nesfatin-1 Obestatin的临床意义

doi:10.3969/j.issn.1006-6233.2021.04.024

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Abstract Objective: To investigate the expression levels and significance of serum Ghrelin, nesfatin-1 and Obestatin in patients with stable coronary heart disease complicated with obesity.Methods: A total of 206 patients with stable coronary heart disease (CHD) admitted to Beijing Chaoyang emergency rescue center from September 2018 to August 2020 were selected and divided into normal group (87 cases), overweight group (72 cases) and obesity group (47 cases) according to the Guidelines for Prevention and Control of Overweight and Obesity in Chinese adults, the levels of high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG) and fasting blood glucose (FBG) were measured, the serum levels of Ghrelin, nesfatin-1 and Obestatin were detected by enzyme-linked immunosorbent assay (ELISA); the basic data of patients were collected; coronary angiography was performed and SYNTAX score was calculated; Spearman was used to analyze the correlation between serum Ghrelin, nesfatin-1 levels and SYNTAX score; Logistic regression model was used to analyze the factors influencing the severity of stable coronary heart disease. Results: The BMI, LDL-C, TC and syntac of the normal group, the hyperrecombination group and the obesity group were increased (P<0.05). HDL-C, ghrelin and nesfatin-1 were decreased (P<0.05), and the serum obestatin levels were not statistically significant (P>0.05). And the difference of the number of pathological changes in the three groups was statistically significant (P<0.05). Spearman analysis showed that serum ghrelin and nesfatin-1 levels were negatively correlated with syntax score (r = -0.532, P = 0.000; r = -0.630, P = 0.000). Multivariate logistic regression analysis showed that BMI, LDL-C and TC were independent risk factors for severe lesions in patients with stable coronary heart disease (P<0.05). Ghrelin and nesfatin-1 were protective factors for severe lesions in patients with stable coronary heart disease (P<0.05). Conclusion: The expression levels of serum Ghrelin and nesfatin-1 in patients with stable coronary heart disease and obesity are closely related to the severity of the disease in patients with stable coronary heart disease, and may become biological auxiliary indicators for evaluating the condition.

Key words： Stable coronary heart disease Obesity Ghrelin Nesfatin-1 Obestatin

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	LU Qinghu
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LU Qinghu,LIU Shigang,et al. Clinical Significance of Serum Ghrelin, Nesfatin-1 and Obestatin in Patients with Stable Coronary Heart Disease and Obesity[J]. HeBei Med, 2021, 27(4): 639-644.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.04.024 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I4/639

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