|
|
Clinical Value of CTPI in the Evaluation of Cerebral Hemodynamics in Patients with Ischemic Cerebrovascular Disease |
ZHU Youyi, GAO Lvping, CAO Chengying, et al |
Qinghai Cardiovascular and Cerebrovascular Hospital, Qinghai Xining 810012, China |
|
|
Abstract Objective: To explore the clinical value of CT perfusion imaging (CTPI) in the evaluation of cerebral hemodynamics in patients with ischemic cerebrovascular disease.Methods: A total of 140 patients with ICVD were selected. All patients underwent cerebral CTPI examination, and the cerebral hemodynamic parameters [cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time to peak (TTP)] were obtained in the healthy side and the affected side of the abnormal perfusion area, and the relative values of perfusion parameters (rCBF, rCBV, rMTT, rTTP, rCBV-rCBF) were calculated in region of interest of the large cerebral hemispheres on both sides. Results: The levels of MTT and TTP in the affected side of the abnormal perfusion area of transient ischemic attack (TIA) patients were higher than those in the healthy side (P<0.05) while the CBF level was lower than that in the healthy side (P<0.05). There was no statistically significant difference in the CBV level compared with that in the healthy side (P>0.05). The levels of MTT and TTP in the affected side of the abnormal perfusion area of cerebral infarction (CI) patients were higher than those in the healthy side (P<0.05) while the levels of CBF and CBV were lower than those in the healthy side (P<0.05). The levels of MTT and TTP in the healthy side or the affected side of the abnormal perfusion area of CI patient were higher than those of TIA patients while the levels of CBF and CBV were lower than those of TIA patients (P<0.05). The levels of rMTT, rCBF, rCBV and rCBV-rCBF of CI patients were lower than those of TIA patients (P<0.05), and there was no significant difference in rTTP level compared with that of TIA patients (P>0.05). The proportion of NIHSS score ≥5 points of CI patients was higher than that of TIA patients (P<0.05). Conclusion: There are abnormal changes in CPTI cerebral hemodynamics in TIA patients and CI patients. The brain reserve capacity and nerve function damage in CI patients are more serious than those in CI patients. CTPI can be used to provide effective hemodynamic information in ischemic cerebrovascular diseases and help to evaluate the disease condition.
|
|
|
|
|
[1] 胡盛寿,杨跃进,郑哲,等.《中国心血管病报告2018》概要[J].中国循环杂志,2019,34(3):209~220. [2] 高安生,李红,钟华阳,等.评估急性脑梗死静脉溶栓治疗后CT灌注变化及疗效[J].中国医学影像技术,2019,35(12):1823~1827. [3] 贾建平,陈生弟,崔丽英,等.神经病学[M].第7版.北京:人民卫生出版社,2013.180. [4] 陆敏智,黄鹏,仲玲玲,等.缺血性脑卒中患者近期功能预后影响因素分析[J].中华物理医学与康复杂志,2018,40(1):38~40. [5] 高爱民,许云鹤,王宁,等.注射用丹参多酚酸联合小剂量川芎嗪治疗缺血性脑血管病50例临床观察[J].山东医药,2019,59(28):77~79. [6] 李佳敏,张婕,熊静.CT灌注成像对缺血性脑血管病患者脑血流动力学的评价[J].中华脑科疾病与康复杂志,2015,5(4):27~30. [7] 张军,张天瑜,潘嘉伟,等.256层CT灌注成像监测急性缺血性脑卒中溶栓前后脑血流动力学变化[J].中国医学计算机成像杂志,2016,22(5):393~397. [8] 朱杰,张蓓,宋彬,等.低剂量全脑CTP在急性脑梗死疗效评估中的价值[J].中国临床医学影像杂志,2017,28(3):157~161. [9] 赵启媛,金平,陈生,等.CT灌注成像在急性缺血性脑血管病中的诊断价值[J].安徽医学,2018,39(7):841~844. [10] 夏倩倩,王希明,张征宇,等.急性缺血性脑卒中CTA侧支等级与CTP之间的相关性研究[J].临床放射学杂志,2019,38(2):224~228. |
|
|
|