经鼻高流量氧疗治疗慢性阻塞性肺疾病合并高碳酸血症疗效及对患者血浆EOS水平和血气分析指标的影响

doi:10.3969/j.issn.1006-6233.2021.04.017

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Abstract Objective: To investigate the efficacy of high-flow nasal cannula (HFNC) in the treatment of chronic obstructive pulmonary disease (COPD) with hypercapnia and its effects on levels of plasma eosinophils (EOS) and blood gas analysis indicators.Methods: The clinical data of 162 patients with severe COPD complicated with hypercapnia during stable stage who received pulmonary rehabilitation therapy in our hospital from January 2015 to June 2020 were retrospectively analyzed. The patients were divided into HFNC group (n=88) and traditional group (n=74) according to the treatment methods after discharge. Both groups were given conventional treatment, and traditional group was additionally treated with traditional nasal catheter oxygen therapy, and HFNC group was additionally treated with HFNC. The lung function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC], blood gas analysis indexes [PH value, arterial partial pressure of oxygen (PaO₂), arterial partial pressure of carbon dioxide (PaCO₂), pulse oxygen saturation (SpO₂)], plasma EOS and exercise endurance [Activities of daily living (ADL), 6min walking test (6MWT)] were compared between the two groups before treatment and after 6 months of treatment. Results: Before treatment, there were no statistical differences in FEV1, FVC, FEV1/FVC, pH value, PaO₂, PaCO₂, SpO₂, EOS, scores of ADL scale and 6MWT between the two groups (all P>0.05). After 6 months of treatment, the FEV1, FVC, FEV1/FVC, PH value, PaO₂, SpO₂ and 6MWT in HFNC group were significantly higher than those in traditional group (P<0.05) while the PaCO₂, EOS and scores of subscales of ADL scale (physical self-care ability, instrumental activities of daily living) were significantly lower than those in traditional group (P<0.05), and the differences before and after treatment were significantly higher than those in control group (P<0.05). Conclusion: HFNC is more effective than traditional low-flow oxygen therapy in pulmonary rehabilitation after discharge in patients with severe COPD complicated with hypercapnia during stable stage, thus it is worthy of promotion.

Key words： High-flow nasal cannula Chronic obstructive pulmonary disease Hypercapnia Eosinophils Blood gas analysis

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	Articles by authors
	ZHOU Xiaoman
	LIN Mei
	ZHANG Yutian

Cite this article:

ZHOU Xiaoman,LIN Mei,ZHANG Yutian. Efficacy of High-flow Nasal Cannula on Chronic Obstructive Pulmonary Disease with Hypercapnia and Its Effects on Levels of Plasma EOS Level and Blood Gas Analysis Indicators[J]. HeBei Med, 2021, 27(4): 604-609.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.04.017 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I4/604

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