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| Changes and Clinical Significance of Inflammatory Factors and Immune Function in Children with OSAHS after Tonsillectomy |
| HOU Le, TAI Xuhui, ZHANG Wei |
| Air Force Hospital, Northern Theater Command of the People's Liberation Army, Liaoning Shenyang 110042, China |
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Abstract Objective: To explore the changes and clinical significance of inflammatory factors and immune function in children with obstrective sleep apnea-hypopnea syndrome (OSAHS) after tonsillectomy. Method: 110 cases with obstructive sleep apnea hypopnea syndrome clinically diagnosed and treated with tonsillectomy in our hospital from June 2018 to June 2019 were selected.110 cases with health examinations at the same time were selected as the control group. The changes of T cell subsets, inflammatory factors and immune function before surgery and half a year after surgery were compared, and the expression and clinical significance of each cytokine in apnea hyponea index (AHI) were analyzed. Results: Before surgery, the levels of CD3+, CD4+, CD8+, CD4+ / CD8+ in the study group were significantly lower than those in the control group, and the levels of TNF-α, IL-6, hn-CRP, IgG, IgM, and IgA were significantly higher than those in the control group (P<0.05). Six months after surgery, there was no significant difference in the levels of CD3+, CD4+, CD8+, CD4+/ CD8+, TNF-α, IL-6, hn-CRP, IgG, IgM, and IgA between the study group and the control group (P>0.05). In patients with OSAHS after tonsillectomy, the levels of IgG, IgM, IgA, TNF-α, IL-6, and hn-CRP increased with the severity of AHI, and the levels of CD3+, CD4+, CD8+, CD4+ / CD8+ decreased with the severity of AHI (P<0.05). According to Spearman correlation analysis, TNF-α, IL-6, hs-CRP, IgA, IgG, IgM were positively correlated with AHI in patients with OSAHS after tonsillectomy, while CD3+, CD4+, CD8+, CD4 + / CD8+ was negatively correlated with AHI (P<0.05). Conclusion: The expression of inflammatory factors and immune function is correlated with the AHI of OSAHS children. According to the expression level, the child's condition can be effectively evaluated.
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2021, Vol. 27 
