|
|
|
| The Correlation Between Type 2 Diabetic Peripheral Neuropathy and Serum 25(OH) Vitamin D3 Level |
| ZHANG Jinhui, WANG Chunyan |
| General Aviation Hospital of Chaoyang District, Beijing 100000, China |
|
|
|
|
Abstract Objective: To investigate the correlation between serum 25 (OH) vitamin D3 (VD3) levels and peripheral neuropathy (DPN) of patients with type 2 diabetes, and to analyze the related influencing factors of DPN.Methods: A total of 135 type 2 diabetes inpatients in the Aviation General Hospital from January 2018 to January 2019 were collected as research subjects. One group included 57 cases of diabetes without type 2 peripheral neuropathy (NDPN), and the other group included 78 patients of diabetes mellitus combined with type 2 peripheral neuropathy (DPN). The clinical data of all subjects for were collected for analysis, the HbA1c, FBG, PBG, Cr, ALT, LDL-C, and VD3 levels of the tested patients were measured, the proportion of the lack of VD3 levels in the NDPN group and the DPN group were counted, and VD3 level of patients in the two groups was compared. Logistic regression was used to analyze the independent risk factors of patients with DPN, and the possible causes of DPN were preliminarily discussed. Results: There was a certain difference in the course of disease and the level of glycosylated hemoglobin between the DPN group and the NDPN group (P<0.05). The average serum VD3 level in the DPN group was (24.55±11.27) ng/ml, and the level in the NDPN group was (50.43±18.48) ng/ml. The VD3 level in the DPN group was lower than that in the NDPN group (P<0.05). 93.6% of the patients in the DPN group had VD3 deficiency, 22.8% of NDPN patients had VD3 deficiency, and the proportion of VD3 deficiency in the DPN group was higher (P<0.05). Regression analysis showed that the course of disease and VD3 are independent risk factors for DPN. Conclusion: VD3 deficiency is relatively common in patients with DPN. In addition, VD3 deficiency is related to the occurrence of DPN. The occurrence and progression of DPN is related to VD3 deficiency.
|
|
|
|
|
|
[1] 吴玉洁.25(OH)D水平与2型糖尿病患者周围神经病变的关系[J].河北医学,2018,24(12):1941~1944.
[2] 文海清,郭娟,雷晓珍,张萍,郜晓彬.青年2型糖尿病患者血清25-羟维生素D_3水平与糖尿病周围神经病变的关系[J].广西医学,2019,41(21):2701~2704.
[3] 王玉虎.维生素D缺乏与糖尿病周围神经病变的相关性分析[J].中国综合临床,2019,(6):508~511.
[4] 李全民,吴海娅.糖尿病周围神经病变诊断标准与检查方法评价[J].中华糖尿病杂志,2018,10(11):705~708.
[5] 郑靖洁,刘映.血清25羟维生素D-3与2型糖尿病周围神经病变的相关性分析[J].世界最新医学信息文摘,2019,19(25):23~24.
[6] 孙田,席小雯,邓庆,李超,梁崇上.维生素D水平与2型糖尿病患者周围神经病变的关系[J].临床医学研究与实践,2019,4(7):24~25.
[7] 苏敏,杜联,谢春光.血清25-(OH)维生素D3与糖尿病周围神经病变相关性研究进展[J].中药与临床,2019,10(1):50~53.
[8] 郑月月,柳德学,石小霞,徐娜,李瑞阁.维生素D_2对2型糖尿病周围神经病变治疗效果的多中心随机单盲干预研究[J].中国慢性病预防与控制,2018,26(7):495~499.
[9] 贺娟,周珺,罗晓红.糖尿病周围神经病变相关血清标记物研究进展[J].中国临床研究,2018,31(5):682~684. |
|
|
|
2021, Vol. 27 
