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| Intrathecal Continuous Infusion of Different Doses of Dexmedetomidine Combined with Sufentanil in Labor Analgesia |
| ZHANG Jinqiang, ZHANG Jie, CHEN Jun, et al |
| Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Hubei Wuhan 430063, China |
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Abstract Objective: To investigate the clinical study of continuous intrathecal infusion of different doses of dexmedetomidine combined with sufentanil in labor analgesia. Methods: 120 full-term pregnant women admitted to our hospital from May 2018 to October 2019 were randomly divided into compatibility group (1:3) and control group A. The experimental group was divided into B1,B2 and B3 subgroups with 30 cases in each. The NRS scores of contractile pain in each group at different time points (before treatment,15min after treatment,1 hour after treatment and full-time opening of cervical orifice) were compared. The baseline fetal heart sounds of each group were compared at each time point (before treatment,15min after treatment,1 hour after treatment and full-time opening of cervical orifice). The second stage of labor was counted in each group. Apgar scores of newborns in each group (at birth,1min after birth and 5 min after birth) were compared. The complications of each group were compared. Results: The NRS scores of contractile pain in group B3 were lower than those in group A,group B1 and group B2,the difference was statistically significant(P<0.05),at 15min after treatment,1h after treatment and full-time opening of the public portal. There was no significant difference in baseline fetal heart sounds in each group at each time point (before treatment,15min after treatment,1h after treatment and full-time opening of cervical orifice) (P>0.05). The second stage of labor in group B3 was shorter than that in group A,group B1 and group B2,the difference was statistically significant(P<0.05). At birth,1 min after birth and 5min after birth,there was no significant difference in neonatal Apgar score (P>0.05). The proportion of uterine agony in group B3 was lower than that in group A,group B1 and group B2,the difference was statistically significant(P<0.05). Conclusion: During labor analgesia,a relative dose (0.04μg/kg) of dexmedetomidine combined with sufentanil can effectively relieve the pain of patients without affecting the fetal heart sound and neonatal asphyxia ratio,and has less complications and high safety.
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2021, Vol. 27 
