|
|
|
| Diagnostic Value of Combined Detection of Serum TK1,CEA,CA72-4 and CA242 for Gastric Cancer |
| ZHANG Xia, LI Peng, SHANG Hongyan |
| Air Force Hospital of Northern Theater of PLA, Liaoning Shenyang 110041, China |
|
|
|
|
Abstract Objective: To investigate the diagnostic efficiency of combined detection of serum thymidine kinase (TK1),carcinoembryonic antigen (CEA),carbohydrate antigen (CA) 72-4 and CA242 for gastric cancer. Methods: 120 patients with gastric cancer who were admitted to the hospital from February 2018 to February 2019 were included in the gastric cancer group. Another 100 patients with gastric diseases who underwent gastroscopy in the hospital for stomach discomfort and 50 healthy adults receiving physical examination during the same period were included in the benign gastric disease group and the control group. Levels of serum TK1,CEA,CA72-4 and CA242 were determined. The indicators were compared between the groups and the diagnostic efficiency of each index was analyzed by ROC curve. Results: The levels of serum TK1,CEA,CA72-4 and CA242 in the gastric cancer group were significantly higher than those in the benign gastric disease group and the control group (P<0.05),without significant difference between the benign gastric disease group and the control group (P>0.05). In the gastric cancer group,serum indexes in patients with advanced gastric cancer were significantly higher than those in patients with early gastric cancer (P<0.05). The areas under the curves of TK1,CEA,CA72-4 and CA242 alone for diagnosis of gastric cancer were 0.781,0.764,0.769 and 0.719,respectively. The areas under the curves of different tumor markers for diagnosis of gastric cancer were larger than that of single diagnosis. The area under the curve of combined diagnosis of the four indexes and TK1,CEA,CA242 combination was larger. Conclusion: The elevation of serum TK1,CEA,CA72-4 and CA242 is witnessed in patients with gastric cancer. The combined diagnosis of these indicators can improve the diagnostic efficiency for gastric cancer.
|
|
|
|
|
|
[1] Feng F,Tian Y,Guo M,et al.Comparison of clinicopathological features and prognosis of gastric cancer located in the lesser and greater curve[J].Clin Transl Oncol,2017,19(4):1~7.
[2] Kang H M,Kim G H,Jeon H K,et al.Circulating tumor cells detected by lab-on-a-disc:Role in early diagnosis of gastric cancer[J].Plos One,2017,12(6):51~53.
[3] 钱东林,李翔翔.血液学指标检测在胃癌诊断中的价值探讨[J].标记免疫分析与临床,2018,25(12):114~117.
[4] Fang C C,Chou C C,Yang Y Q,et al.Multiplexed detection of tumor markers with multicolor polymer dot-based immunochromatography test strip[J].Anal Chem,2017,9(10):11~15.
[5] Bagegni N,Thomas S,Liu N,et al.Serum thymidine kinase 1 activity as a pharmacodynamic marker of cyclin-dependent kinase 4/6 inhibition in patients with early-stage breast cancer receiving neoadjuvant palbociclib[J].Breast Cancer Res,2017,19(1):123.
[6] Lou X,Zhou J,Ma H,et al.The half-life of serum thymidine kinase 1 concentration is an important tool for monitoring surgical response in patients with lung cancer:A Meta-Analysis.[J].Genet Test Mol Biomarkers,2017,21(8):471.
[7] Feng F,Tian Y,Xu G,et al.Diagnostic and prognostic value of CEA,CA19-9,AFP and CA125 for early gastric cancer[J]. Bmc Cancer,2017,17(1):737.
[8] Gero E J,Colcher D,Ferroni P,et al.CA 72-4 radioimmunoassay for the detection of the TAG-72 carcinoma-associated antigen in serum of patients[J].Clin Lab Anal,2015,3(6):360~369.
[9] 胡召锁,徐元宏.血清胃泌素17、胸苷激酶1、癌胚抗原、糖类抗原19-9、12-5、72-4联合检测在胃癌中的诊断价值[J].中国老年学杂志,2015,11(8):2107~2108.
[10] 江蓓蕾,鲍扬漪,叶艳.TK1与肿瘤标志物在消化道肿瘤诊断及病理学特征的相关性[J].安徽医科大学学报,2018,53(11):110~114. |
| [1] |
. [J]. HeBei Med, 2020, 26(5): 829-832. |
|
|
|
|
2021, Vol. 27 
