早发型新生儿败血症NLR ELR和PLR指标变化及临床意义

doi:10.3969/j.issn.1006-6233.2021.03.022

Abstract
Figure/Table
References
Related Citation (4)

Download: PDF (1327 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To observe the clinical significance and the changes on the neutrophil-to-lymphocyte, the eosinophil-to-lymphocyte, the platelet-to-lymphocyte with Neonatal septicemia. Methods: From April 2017 to May 2020, 58 newborns with early-onset sepsis in our hospital were selected as sepsis group, and 40 non infected newborns in the same period were selected as control group. The levels of NLR, ELR and PLR were compared between the two groups. The changes and clinical significance of NLR, ELR and PLR in early-onset neonatal sepsis were evaluated. Results: The levels of NLR and ELR in sepsis group were significantly higher than those in control group (P<0.05). ROC curve analysis showed that area under the curve NLR > ELR > PLR, NLR cutoff value was 1.987, sensitivity was 78.87%, specificity was 88.11%, area under the curve was 0.752, ELR cutoff value was 0.117, sensitivity was 70.81%, specificity was 77.25%, area under the curve was 0.689. Conclusion: The diagnostic efficiency of NLR is higher than that of ELR, which can assist in the diagnosis of early-onset neonatal sepsis, and has a certain reference value for the diagnosis and evaluation of children's diseases.

Key words： Neonatal septicemia NLR ELR PLR Early-onset

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.03.022 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I3/457

[1] 周启立,刘利蕊,郭健.白细胞介素-6、降钙素原、C-反应蛋白对足月新生儿社区获得性败血症晚发型的早期诊断价值[J].中国妇幼保健,2019,34(8):1770~1773.
[2] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].第5版.南京:人民卫生出版社,2018.582~584.
[3] Gao SQ,Huang LD,Dai RJ,et al.Neutrophil-lymphocyte ratio: a controversial marker in predicting crohn's disease severity[J].Int Clin Exp Pathol,2015,8(11): 14779~14785.
[4] 陈文,张晓峰,张健,等.支气管哮喘急性发作期血细胞比值的变化及临床意义[J].医学综述,2019,25(13):2506~2510.
[5] 张晓峰,陈文,张健,等.急性发作期哮喘患者血小板参数的变化及其临床意义[J].慢性病学杂志,2019,22(5):303~304.
[6] 陈瑩,周张青,唐猛,等.外周血NLR在评估重度支气管哮喘急性发作期患者预后的意义[J].浙江临床医学,2018,20(4):717~719.
[7] 胡亚美,江载芳,申昆玲,等.诸福棠实用儿科学[M].第8版,北京:人民卫生出版社,2015.1255~1262.
[8] Ashraf G M,Tarasov V V,Makhmutov A A,et al.The possibility of an infectious etiology of alzheimer disease[J].Mol Neurobiol,2019,56(6):4479~4491.
[9] 时小淋,王晓丰,刘鹏,等.中性粒细胞杀菌机理的最新研究进展[J].现代检验医学杂志,2020,35(1):161~164.
[10] Che-Morales J L,Cortes-Telles A.Neutrophil-to-lymphocyte ratio as a serum biomarker associated with community acquired pneumonia[J].Rev Med Inst Mex Seguro SOC,2019,56(6): 537~543.
[11] 朱振君,宋桂玲,江铁成, 等.新生儿细菌感染性肺炎s-TREM-1、血清a-AT和WBC的相关性研究[J].河北医药,2019,41(7):77~79,83.
[12] 谭君心,符纯川,李国华,等.血小板/淋巴细胞比值和肿瘤直径与肝细胞癌微血管侵犯的相关性[J].标记免疫分析与临床,2020,27(1):48~52.
[13] 李治琴,郑朝晖,杜望磊,等.血小板/淋巴细胞比值和粒细胞/淋巴细胞比值与大动脉炎疾病活动性的关系[J].中华心血管病杂志,2018,46(9):713~718.
[14] 陈素云,赵志新,颜海希,等.中性粒细胞/淋巴细胞比率和前蛋白对脓毒血症患者预后评价研究[J].中国卫生检验杂志,2019,29(20):2524~2527,2533.
[15] 韩伟平,肖洋,李瑞华.中性粒细胞CD64指数、PCT、NLR在感染性疾病诊断中的价值.[J].中国微生态杂志,2019,30(3):304~307,311.
[16] 徐莉,杜娟,周亚红,等.新生儿嗜酸性粒细胞增多症与学C反应蛋白、B2微球蛋白的相关研究[J].湖南中医药大学学报,2012,32(12):45~46.
[17] 余小云,蔡莉,林敏,等.NLR、PLR和RDW对医院获得性肺炎病情严重程度及预后的评估价值[J].江西医药,2020,55(10):1468~1470.