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| Diagnostic Value of Serum CA125 and Human Epidiymis Protein 4 for Epithelial Ovarian Cancer and Its Relationship with Clinical Pathological Characteristics and Prognosis |
| DENG Meixian, et al |
| The Fifth Hospital of Wuhan, Hubei Wuhan 430050, China |
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Abstract Objective: To analyze the diagnostic value of serum carbohydrate antigen 125 (CA125) and human epidiymis protein 4 (HE4) for epithelial ovarian cancer and its relationship with clinical pathological characteristics and prognosis. Methods: The clinical data of 96 patients with epithelial ovarian cancer (malignant group) and 90 patients with benign ovarian disease (benign group) admitted in our hospital from April 2014 to April 2019 were retrospectively analyzed. Serum HE4 and CA125 levels were compared,and the results of pathological diagnosis were used as the gold standard to compare the sensitivity,specificity and accuracy of serum HE4 and CA125 levels in the diagnosis of epithelial ovarian cancer and benign ovarian disease. The clinicopathological characteristics and short-term prognosis of all patients with epithelial ovarian cancer were recorded. The expressions of serum HE4 and CA125 in patients with different pathological features were compared,and logistic regression model was used to analyze the independent risk factors affecting the prognosis of patients with epithelial ovarian cancer. Results: The levels of HE4 and CA125 in the malignant group were higher than those in the benign group (P<0.05). The clinical efficacy of serum HE4 in the diagnosis of epithelial ovarian cancer is higher than that of serum CA125 (P<0.05). The sensitivity and accuracy of the combined diagnosis of serum HE4 and CA125 were 96.88% and 94.09%,respectively,which were higher than those of any single serum detection (P<0.05),and there was no difference in the specificity between the combined diagnosis and single serum HE4 diagnosis (P>0.05).The positive expression rates of serum HE4 and CA125 in patients with FIGO stage Ⅲ + Ⅳ and low differentiation are higher than those in patients with FIGO stage Ⅰ + Ⅱ and medium and high differentiation (P<0.05). The patients who are in FIGO stage Ⅲ + Ⅳ,and have low degree of differentiation,CA125> 500U / ml,positive serum HE4 and lymphatic metastasis have low survival rates (P<0.05). FIGO stage Ⅲ + Ⅳ,lymphatic metastasis,low degree of differentiation,CA125> 500U / mL,and positive HE4 are independent risk factors affecting the prognosis of patients with epithelial ovarian cancer (P<0.05). Conclusion: ① Serum HE4 and CA125 are highly expressed in patients with epithelial ovarian cancer,which can be used as an early screening method in the high population,but the clinical value of combined diagnosis is better than that of single serum detection. ②The expression levels of serum HE4 and CA125 are closely related to the clinicopathological characteristics and prognosis of patients. FIGO stage Ⅲ+Ⅳ,lymphatic metastasis,low degree of differentiation,CA125> 500U / mL,positive HE4 are independent risk factors that affect the prognosis of patients with epithelial ovarian cancer,and can be used as an effective indicator to predict the prognosis of patients.
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2021, Vol. 27 
