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| Correlation Study of Oxygenation Index Platelet Count and Plasma PCT Level with the Severity of Sepsis |
| LI Chuan, FANG Changtai, CHA Junjing, et al |
| Anqing Municipal Hospital, Anhui Anqing 246003, China |
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Abstract Objective: To explore the correlation between oxygenation index,platelet count (PLT) and plasma procalcitonin (PCT) level and the severity of sepsis. Methods: A retrospective analysis was performed among 126 sepsis patients admitted to the hospital between January 2018 and October 2020,and the subjects were divided into sepsis group (n=38),severe sepsis group (n= 47) and septic shock group (n=41) according to the severity. General clinical data and laboratory indicators of the 3 groups were comparatively analyzed,and the correlations among oxygenation index,PLT,PCT,the acute physiology and chronic health evaluation II (APACHEⅡ) score and the sequential organ failure assessment (SOFA) score were analyzed. Meanwhile,ROC curve was used to analyze the value of oxygenation index,PLT and PCT in evaluating death in patients with sepsis within 28 days after admission. Results: The APACHE Ⅱ score,SOFA score and the mortality rate within 28 days after admission were significantly higher in the septic shock group than in the severe sepsis group and the sepsis group (P<0.05). There were significant differences in red blood cell distribution width (RDW),white blood cell count (WBC),PLT,C-reactive protein (CRP),serum creatinine (Scr),PCT,blood lactate and oxygenation index among the 3 groups (P<0.05). Besides,the septic shock group had the highest RDW,WBC,CRP,Scr,PCT and blood lactate levels,and the lowest PLT and oxygenation index (P<0.05). The oxygenation index,and PLT was significantly negatively correlated with APACHEⅡ score and SOFA score (P<0.05),while PCT was significantly positively correlated with APACHEⅡ score and SOFA score (P<0.05). Oxygenation index and PLT in patients with sepsis were positively correlated with PLT,but negatively with PCT Correlation (P<0.05); PLT and PCT were negatively correlated (P<0.05). ROC curve analysis showed that oxygenation index,PLT and PCT could predict 28 days mortality of patients with sepsis,and the area under curve (AUC) was 0.728,0.799 and 0.762,respectively. Conclusion: Oxygenation index,PLT and PCT are related to the condition of patents with sepsis,indicating prognostic value. Besides,the expression levels of the three indexes are correlated in patients with sepsis. They can be used as auxiliary clinical indicators for diagnosis and evaluation of sepsis.
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2021, Vol. 27 
