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| Analysis of Clinical Efficacy and Safety of Propranolol Combined with Methimazole and Propylthiouracil in Patients with Hyperthyroidism |
| YAO Xiaoyan, XIE Zhouni, ZHOU Li |
| Guilin People's Hospital in Guangxi Province, Guangxi Guilin 541002, China |
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Abstract Objective: To investigate the clinical efficacy of propranolol combined with methimazole and propylthiouracil on hyperthyroidism. Methods: 180 patients with hyperthyroidism were selected as the research objects. The study period was from October 2015 to October 2017. According to a Simple Random Method Using Simple Data, They were divided into a control group (treated with propranolol and propylthiouracil) and observation Sheet Group (given propranolol combined with methimazole treatment), 90 cases in each group, and the total effective rate, free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone ( TSH), osteocalcin (OCN), type I collagen carboxy-terminal peptide β-special sequence (β-CTX) and the incidence of adverse reactions were observed and evaluated. Results: The total effective rate of the observation group was higher than that of the control group (χ2=12.291, P＜0.05). After 3 months of treatment, the observation group's FT3, FT4, OCN, β-CTX were lower than the control group, while TSH was higher than the control group (P<0.05); and the observation group FT3, FT4, TSH, OCN, β-CTX The difference before and after treatment was greater than that of the control group (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (χ2=5.178, P＜0.05). Conclusion: Propranolol combined with methimazole has a good effect in the treatment of patients with hyperthyroidism, which can regulate the level of thyroid hormones and ensure safety.
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2021, Vol. 27 
