自体脂肪间充质干细胞治疗躯干部位带状疱疹后神经痛的临床研究

doi:10.3969/j.issn.1006-6233.2021.02.018

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Abstract Objective: To investigate the clinical effect of autologous adipose derived mesenchymal stem cells in the treatment of trunk part (thoracic 3-lumbar 12 segments) postherpetic neuralgia. Methods: 110 patients with trunk part (thoracic 3-lumbar 12 segments) postherpetic neuralgia treated in our hospital from February 2017 to March 2020 were selected as the research objects, and were randomly divided into stem cell group and radiofrequency group (55 cases in each group). The patients in the radiofrequency group were treated with conventional nerve root pulse radiofrequency block, and the stem cell group were treated with autologous adipose derived mesenchymal stem cells. The clinical efficacy, incidence of adverse reactions, satisfaction with pain control, visual analogue scoring(VAS) score, quality of life score and sequelae symptoms (itching, tight binding, ant walking) incidence rate before and after treatment were compared between the two groups. Results: The clinical effect of the stem cell group (92.73%) was higher than that of the radiofrequency group (76.36%)(P<0.05). After 1 and 3 months of treatment, the VAS scores of the two groups were significantly decreased (P<0.05), and the VAS scores in the stem cell group was lower than the radiofrequency group (P<0.05). After 1 and 3 months of treatment, the scores of sleep, diet, emotion, daily life and other quality of life of the two groups were significantly decreased (P<0.05), and the scores in the stem cell group was lower than that of the radiofrequency group (P<0.05). The incidence of adverse reactions in the stem cell group was lower than that in the radiofrequency group (5.45% vs 21.28%, P<0.05), and the pain control satisfaction was higher than that in the radiofrequency group (90.91% vs 70.91%, P<0.05). After treatment, the itching, tight binding and ant sense of the two groups were significantly reduced, and the incidence of itching, tight binding and ant sense in the stem cell group was significantly lower than that in the radio frequency group (P<0.05). Conclusion: Autologous adipose derived mesenchymal stem cells have a good clinical effect in the treatment of patients with trunk part (thoracic 3-lumbar 12 segments) postherpetic neuralgia, which can effectively relieve the degree of pain, improve the quality of life of patients, significantly reduce the incidence of adverse reactions and sequelae symptoms, improve the satisfaction of pain control, so it is worthy of clinical application.

Key words： Autologous adipose derived mesenchymal stem cells Postherpetic neuralgia Pulsed radiofrequency block

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	ZHANG Hong
	ZHANG Shuli
	YAN Baili
	et al

Cite this article:

ZHANG Hong,ZHANG Shuli,YAN Baili, et al. Clinical Study of Autologous Adipose Derived Mesenchymal Stem Cells in the Treatment of Trunk Part Postherpetic Neuralgia[J]. HeBei Med, 2021, 27(2): 259-264.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.02.018 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I2/259

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