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| Effects of Vardenafil on the Hearing Function and Cochlea Morphology of Guinea Pigs with Drug Induced Hearing Loss |
| LIANG Yuan, HUANG Yueyan, GUO Xia, et al |
| The Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: To study the effects of vardenafil on the hearing function and cochlea morphology of guinea pigs with drug induced deafness. Methods: Guinea pigs were randomly divided into blank control group, model control group and treatment group, 10 in each group. Two weeks after gentamicin 120mg·kg-1·d-1 injected into Guinea pigs of treatment group and model control group,vardenafil (1mg·kg-1·d-1) and NS(4ml·kg-1·d-1) were injected into Guinea pigs of the above two groups respectively. ABR thresholds were measured respectively prior to the experiment, 1,2 and 4 weeks post-drugs. The morphological changes of cochlea hair cells were observed by scanning electron microscope. Results: After 2 weeks of gentamicin administration, the ABR threshold of treatment group and model control group were significantly higher than that of the blank control group, with statistically significant differences (all P values <0.01). After vardenafil injection, the ABR threshold shift in the treatment group was smaller than that in the model control group, and the difference was statistically significant (all P<0.01). SEM showed that hair cells of the inner and outer hair cells in model control group displayed mess, fusion and imperfections. In the treatment group, the hair cells displayed slight pathological changes, there wasn't significant difference compared with blank control group. Conclusion: Vardenafil can effectively reduce the damage degree of guinea pig cochlea hair cells caused by gentamicin, which shows that it has obvious improvement effect on drug-induced hearing impairment.
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2021, Vol. 27 
