丁苯酞联合阿替普酶治疗对急性缺血性脑卒中患者神经功能凝血功能血清TNF-α hs-CRP Hcy水平的影响

doi:10.3969/j.issn.1006-6233.2021.01.035

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Abstract Objective: To observe the clinical effect and safety of Ateplase combined with Agatroban on acute ischemic stroke (AIS) and its influence on neurological function and coagulation function and serological indexes such as high sensitive C reaction protein (hs-CRP)、tumornecrosis factor-α (TNF-α) and homocysteine (Hcy). Methods: A total of 134 patients with AIS were selected and divided into two groups by random number table method. The control group consisted of 67 patients who received basic treatment + alteplase and the combination group received basic treatment + alteplase + butylphthal. Both groups were treated for 2 weeks, and the clinical efficacy was compared. National Institutes of Health Stroke Scale (NIHSS), cerebral infarction volume, neuron-specific enolase (NSE), S100β protein, fibrinogen (FIB), D-dimer (D-D), prothrombin time (PT) , activated partial thromboplastin time (APTT), TNF-α, hs-CRP and Hcy was evaluated, detected, and compared. Results: The efficacy of the combination group was better than control group, respectively,with significant difference (P<0.05). Comparison before treatment revealed that the NIHSS score, cerebral infarction volume, NSE, S100β, FIB and D-D in the two groups were lower, and APTT and PT were increased after treatment. Compared with the control group, and NIHSS score, cerebral infarction volume, NSE, S100β, FIB and D-D in combination group was lower, while APTT and PT were increased after treatment, suggesting significant difference (P<0.05). After treatment, the TNF-α, hs-CRP, and Hcy in both groups were lower than those before treatment, and the TNF-α, hs-CRP, and Hcy in the combination group were lower than the control group, with statistical significance (P <0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Butylphthal combined with alteplase can improve the treatment effect, promote nerve function recovery, improve coagulation function, reduce the inflammatory reaction, and has good safety of patients with AIS, compared to the alteplase alone treatment.

Key words： Butyphthal Alteplase Acute ischemic stroke Neurological function Coagulation function inflammation

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	LIU Haichao
	YAN Jianwei
	EN Hongfeng
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LIU Haichao,YAN Jianwei,EN Hongfeng, et al. Effect of Butyphthal Combined with Alteplase on Neurological Function and Coagulation Function and Serological Indexes as TNF-α hs-CRP and Hcy in Patients with Acute Ischemic Stroke[J]. HeBei Med, 2021, 27(1): 150-155.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.01.035 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I1/150

[1] Song TJ,Kim J,Song D, et al. Total cerebral small-vessel disease score is associated with mortality during follow-up after acute ischemic stroke[J].Clin Neurol, 2017, 13(2):187~195.
[2] 赵岩,吕涌涛.尿激酶对脑组织影响的研究进展[J].中国医药导报,2017,14(11):43~46.
[3] 朱烨,吴雅利,李宝香,等.丁苯酞联合阿替普酶对急性脑梗死患者神经功能、认知功能和Hcy等血清学指标的影响[J].中国药房,2018,29(8):1095~1098.
[4] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666~682.
[5] 谷聚贤,安泽鑫,王妍,等.阿替普酶联合阿加曲班治疗急性缺血性脑卒中的效果观察及对神经功能、炎性因子的影响[J].临床误诊误治,2019,32(12):44~49.
[6] 陈海云,何超明.丁苯酞联合依达拉奉治疗通过降低颈动脉内膜中膜厚度改善老年急性脑梗死患者神经功能[J].中国动脉硬化杂志,2019,27(1):74~77.
[7] Purrucker J C, Rizos T, Haas K, et al. Coagulation testing in intracerebral hemorrhage related to non-vitamin K antagonist oral anticoagulants[J]. Neurocrit Care, 2017,27(2):208~213.
[8] Acibuca A, Vurgun VK, Gerede DM, et al. Serum neuron-specific enolase, a marker of neuronal injury, increases after catheter ablation of atrial fibrillation[J].Int Med Res, 2018, 46(11):4518~4526.
[9] 王洪志,张静波,于远军.丁苯酞联合阿替普酶治疗对急性缺血性脑卒中患者血清NSE、S100β水平的影响[J].卒中与神经疾病,2017,24(6):530~533.
[10] 褚洪高,唐倩,赵洋.阿替普酶联合丁苯酞对急性脑梗死患者神经功能及血清应激因子的影响[J].解放军医药杂志,2017,29(6):103~106.
[11] Shi Z, Liu S, Guan Y, et al. Changes in total homocysteine levels after acute stroke and recurrence of stroke[J]. Sci Rep, 2018, 8(1):6993~6998.
[12] Zhao Y, Lee JH, Chen D, et al. DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice[J]. Neurochem Int, 2017, 111 (1):82~92.