不同剂量氟伐他汀对急性心肌梗死患者远期血脂MMP-9因子及左心室重构的影响

doi:10.3969/j.issn.1006-6233.2021.01.031

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Abstract Objective: To study the effects of different doses of fluvastatin on long-term blood lipid, MMP-9 factor and left ventricular remodeling in patients with acute myocardial infarction (AMI). Methods: A total of 192 AMI patients who were admitted to the hospital between January 2017 and March 2019 were randomly divided into high-dose group and low-dose group. And there were 93 cases and 94 cases in the above two groups completing the treatment, respectively. On basis of routine treatment, low-dose group had 40 mg/d fluvastatin, while high-dose group had 80 mg/d fluvastatin. All were treated for 6 months. The left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDd), left ventricular end systolic diameter (LVESd), levels of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), matrix metalloprotein-9 (MMP-9), N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in both groups before and after treatment were detected. The occurrence of adverse reactions during treatment in both groups was statistically analyzed. Results: After treatment, levels of TC, TG, LDL-C, MMP-9, NT-proBNP and cTnT were significantly decreased, while level of HDL-C was significantly increased in both groups (P<0.05). After treatment, decrease amplitude of TC, LDL-C, MMP-9, NT-proBNP and cTnT in high-dose group was significantly less than that in low-dose group (P<0.05). After treatment, LVEF was significantly increased, while LVEDd and LVESd were significantly decreased in both groups (P<0.05). After treatment, change amplitude of LVEF, LVEDd and LVESd in high-dose group was significantly greater than that in low-dose group (P<0.05). The adverse reactions in both groups were mainly on nausea, dizziness, abdominal pain and hypotension. There was no significant difference in the incidence of adverse reactions between high-dose group and low-dose group (21.51% vs 17.02%) (P>0.05). Conclusion: Fluvastatin can effectively interfere with blood lipid level in AMIpatients, reduce levels of MMP-9 factors, and inhibit left ventricular remodeling. The curative effect of high-dose (80 mg/d) fluvastatin is better.

Key words： Fluvastatin Acute myocardial infarction Blood lipid Matrix metalloprotein-9 Left ventricular remodeling

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	CHEN Donglin
	DENG Xiaolan
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CHEN Donglin,DENG Xiaolan,et al. Effects of Different Doses of Fluvastatin on Long-Term Blood Lipid MMP-9 Factor and Left Ventricular Remodeling in Patients with Acute Myocardial Infarction[J]. HeBei Med, 2021, 27(1): 131-135.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.01.031 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I1/131

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