不同血液净化方式对维持性血液透析患者矿物质及骨代谢状况的影响

doi:10.3969/j.issn.1006-6233.2021.01.024

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Abstract Objective: To investigate the effect of hemoperfusion combined with hemodialysis and hemodiafiltration on mineral and bone metabolism in patients with maintenance hemodialysis. Methods: A total of 90 cases of MHD patients were selected from January 2017 to September 2019. Those patients were divided into two groups with 45 cases each according to the random number table method. The observation group was treated with hemoperfusion combined with hemodialysis, while the control group was treated with hemodiafiltration. The treatment lasted for 6 months. The renal function, mineral and bone metabolism of the two groups were compared before and 6 months after treatment, and the clinical symptoms of the two groups were observed. Results: After treatment, the levels of serum creatinine (Scr), blood urea nitrogen (BUN) and β2-MG were significantly reduced in both groups, and the levels of those indexes in the observation group were lower than those in the control group (P<0.05). After treatment, the incidences of skin pruritus, joint pain, muscle weakness and hypertension in the observation group were significantly lower than those in the control group (P<0.05). After treatment, there was no significant change in blood calcium level in the two groups compared with before treatment (P>0.05), while the blood phosphorus level in the observation group was significantly lower than that in the control group (P<0.05). The serum levels of osteoprotegerin (OPG), Bone morphogenetic protein-2 (BMP-2) and bone alkaline phosphatase (BALP) in the two groups were significantly reduced, and the observation group was lower than the control group after treatment (P<0.05). Conclusion: Hemoperfusion combined with hemodialysis can effectively improve the clinical symptoms of MHD patients and correct abnormal mineral and bone metabolism.

Key words： Hemoperfusion Maintenance hemodialysis Hemodiafiltration Calcium and phosphorus metabolism Abnormal bone metabolism

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.01.024 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I1/105

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