胸腔镜食管癌切除术患者术后血清Stathmin VEGF-C表达与复发转移的相关性分析

doi:10.3969/j.issn.1006-6233.2021.01.022

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Abstract Objective: To analyze the correlation between the expression of serum microtubule disaggregation protein (Stathmin), vascular endothelial growth factor (VEGF-C) and recurrence, metastasis after thoracoscopic resection of esophageal cancer. Methods: 105 patients undergoing thoracoscopic resection of esophageal cancer in the hospital were selected as the research subjects, and their clinical data were collected. They were divided into the recurrence and metastasis group and non-recurrence or metastasis group according to whether the patient had recurrence or metastasis after operation. The clinical data, postoperative serum Stathmin and VEGF-C levels were compared between the two groups. Multivariate Logistic regression analysis was performed to analyze the risk factors for recurrence and metastasis after thoracoscopic resection of esophageal cancer. Results: In this study, there were 40 cases with recurrence and metastasis after thoracoscopic resection of esophageal cancer, accounting for 38.10%, the median recurrence time was 18 months. Postoperative serum Stathmin and VEGF-C levels in the recurrence and metastasis group were significantly higher than those in the non-recurrence or metastasis group (P<0.05). There were significant differences in pathological staging, depth of tumor invasion, the maximum diameter of the lesion and postoperative adjuvant radiochemotherapy between the two groups (P<0.05). Multivariate Logistic regression analysis showed that pathological staging, the maximum diameter of the lesion, depth of tumor invasion, postoperative serum Stathmin and VEGF-C levels were closely related to tumor recurrence and metastasis after thoracoscopic resection of esophageal cancer (P<0.05). Conclusion: There is a correlation between the expression of serum Stathmin, VEGF-C and recurrence, metastasisin after thoracoscopic resection of esophageal cancer. The two have great predictive value for postoperative recurrence and metastasis.

Key words： Esophageal cancer Thoracoscopic resection of esophageal cancer Microtubule disaggregation protein Vascular endothelial growth factor Recurrence and metastasis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.01.022 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I1/97

[1] 薛志芳,王丽,奚月,等.术前营养评估及干预对食管癌患者临床疗效影响的对照研究[J].重庆医学,2018,47(6):853~856.
[2] 谢天鹏,向润,杨晓军,等.食管癌术后一年内复发的特点及相关因素分析[J].中华肿瘤杂志,2016,38(2):146~149.
[3] 王来,朱孟沙,田君海,等.Six1和TGF-β及VEGFC在人喉鳞状细胞癌裸鼠移植瘤淋巴转移中的作用[J].临床耳鼻咽喉头颈外科杂志,2016,30(24):1960~1964.
[4] Lin Y, Rong B, Li W, et al. Stathmin overexpression is associated with growth, invasion and metastasis of lung adenocarcinoma[J]. Oncotarget, 2017, 8(16):26000~26012.
[5] 唐健,刘枫,陈洁,等.大范围早期食管癌内镜黏膜下剥离术后发生难治性狭窄的危险因素分析[J].中华消化内镜杂志,2017,34(6):385~388.
[6] 曹小琴.非高发区食管癌筛查人群食管病理分布[J].中国肿瘤,2019,28(10):731~737.
[7] 陈茹,郑荣寿,张思维,等.2015年中国食管癌发病和死亡情况分析[J].中华预防医学杂志,2019,53(11):1094~1097.
[8] 柯彬,吴亮亮,刘宁,等.微管不稳定蛋白Stathmin在胃癌组织中的表达及其意义[J].中华普通外科杂志,2012,27(5):423~424.
[9] 黄敏,余跃,张旭,等.Stathmin在胰腺癌中的表达及意义[J].安徽医科大学学报,2016,51(3):446~449.
[10] 苏文兵,杨丽.胸苷激酶1、Stathmin在食管鳞癌患者血清中的表达及应用价值[J].中国临床医生杂志,2018,46(1):47~49.
[11] Belletti B, Baldassarre G. Stathmin: a protein with many tasks. New biomarker and potential target in cancer[J]. Expert Opinion on Therapeutic Targets, 2011, 15(11):1249~1266.
[12] Po'Uha S T, Grand M L, Brandl M B, et al. Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration[J]. British Journal of Cancer, 2019, 122(3):1~11.
[13] 王翡,刘雪梅.分化型甲状腺癌组织XRCC1和血管内皮细胞生长因子C(VEGF-C)的表达及临床意义[J].细胞与分子免疫学杂志,2017,33(11):1550~1553.
[14] 马俊,鲁建军,缪蓉,等.食管鳞状细胞癌组织中血管内皮生长因子C、D的表达变化及意义[J].山东医药,2016,56(37):90~92.
[15] 陈传凤,吴海卫,高强.食管癌患者术后复发的危险因素分析[J].癌症进展,2018,16(11):83~86.
[16] 彭凯明,林济红,余绍斌,等.pT1胸段食管鳞癌根治术后复发转移的危险因素分析[J].临床外科杂志,2018,26(9):657~661.