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| Correlation Analysis of Peripheral Blood Lymphocyte Count Monocyte Count Lymphocyte to Monocyte Ratio and Clinical Data and Prognosis of Patients with Multiple Myeloma |
| MENG Sha, ZHANG Yang, YUE Xi, et al |
| West China Hospital, Sichuan University, Sichuan Chengdu 610041, China |
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Abstract Objective: To explore the correlations among peripheral blood absolute lymphocyte count (ALC), absolute monocyte count (AMC), lymphocyte to monocyte ratio (LMR) and clinical data and prognosis in patients with multiple myeloma (MM). Methods: A total of 115 patients with newly diagnosed MM who were treated in the hospital from March 2016 to August 2019 were selected as the research subjects. Data such as ALC, AMC and LMR were collected, and the overall survival (OS) was statistically analyzed. Results: ① The peripheral blood ALC of the 115 patients with MM was (0.22~13.48)×109L-1, with an average of (1.77±0.45)×109L-1. The peripheral blood AMC was (0.01~0.98)×109L-1, with an average of (0.45±0.12) ×109L-1, and LMR was 1.18~12.74, with an average of 4.74±0.85. ② With median values of peripheral blood ALC, AMC and LMR as cut-off values, the patients were grouped. Differences between high ALC group and low ALC group, high AMC group and low AMC group in terms of hemoglobin (Hb), lactate dehydrogenase (LDH), β2-microspheres (β2-MG) were statistically significant (P<0.05). Differences in Hb and β2-MG between high LMR group and low LMR group were statistically significant (P<0.05). ③ Kaplan-Meier survival curves showed that the overall OS of high ALC group, low AMC group and high LMR group was significantly longer than that of low ALC group, high AMC group, and low LMR group (P<0.05). ④ Cox multivariate analysis showed that DS stage III, LDH>245U/L, Hb≤110g/L, ALC≤0.65×109L-1 and LMR≤3.85 were independent risk factors for poor prognosis of patients with initial treatment of MM (P<0.05). Conclusion: ALC, AMC and LMR of patients with MM are related to the clinical data and prognosis. Clinically, the results can be used to initially evaluate and predict the prognosis and guide clinical treatment.
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2021, Vol. 27 
