|
|
|
| Effects of Dexmedetomidine on Recovery Quality and Serum IL-1β and TNF- α Levels in Resuscitation of Sevoflurane Inhalation Anesthesia |
| CHEN Bo, YU Mingshuai, LUO Heng |
| The Second Affiliated Hospital of Chengdu Medical College/416 Hospital of Nuclear Industry, Sichuan Chengdu 646000, China |
|
|
|
|
Abstract Objective: To investigate the effect of dexmedetomidine on recovery quality and serum IL-1β and TNF-α levels in resuscitation stage of sevoflurane inhalation anesthesia . Methods: A total of 108 patients underwent laparoscopic cholecystectomy in our hospital from March 2016 to March 2020 were selected and randomly divided into two groups based on the random number table method, with 54 patients in each group. In the study group, dexmedetomidine was continuously pumped after sevoflurane inhalation, while in the control group, constant dose of normal saline was continuously pumped. Perioperative indicators, incidence of agitation and serum inflammatory factors (IL-1β, TNF-α) were compared. Results: There were no statistically significant differences in intraoperative infusion volume, recovery time of spontaneous breathing, tracheal extubation time or awakening time between the two groups (P>0.05).The generalized equation analysis showed that the incidence of agitation in waking period in the study group was lower than that in the control group at different time points (Waldχ2group=4.097, Waldχ2time point=30.388, Pgroup=0.043, Ptime point<0.001). Results of repeated measurement variance showed that VAS score, serum TNF- and IL-1 levels were significantly different between the two groups at different time points (P<0.05); The VAS score, serum TNF-α and IL-1β of the study group were significantly lower than those of the control group (P<0.05). Conclusion: Dexmedetomidine in sevoflurane inhalation anesthesia can effectively improve the postoperative recovery quality of patients, reduce restlessness of patients during convalescence, and has an important role in the reduction of inflammatory response in patients.
|
|
|
|
|
|
[1] Bishr H, Holly G, Ashlee H . Avoiding general anesthesia in treating port-wine stains in infants to avoid neurotoxic events:risk-benefit ratio still undefined[J]. JAMA Dermatology,2019,155(8):983~984.
[2] 李光强,李艳,蔡弥松,等.帕瑞昔布钠联合右美托咪定对甲状腺术患者术后苏醒及疼痛的影响[J].现代医学,2019,47(8):946~950.
[3] 王叶庆.右美托咪定联合氯诺昔康对全髋关节置换术后躁动应激反应的影响[J].河北医学,2019,25(1):45~49.
[4] 何永军,金玮蔚,方弘伟.丙泊酚与七氟烷对单肺通气状态下胸科手术患者炎症因子和肺功能影响的对比分析[J].中华全科医学,2018,16(12):2021~2023,2031.
[5] 张宏伟,张新安,李文瑶,等.右美托咪定对胸腔镜食管癌根治术老年患者认知功能及血清炎症因子、神经损伤标志物水平的影响[J].山东医药,2017,57(23):75~77.
[6] 刘丽,尹志辉,董月稳,等.右美托咪定对老年骨科手术病人炎症反应及氧化应激指标的影响[J].蚌埠医学院学报,2017,263(11):59~63.
[7] 王英姿,彭志勇,殷爽,等.右美托咪定复合腹横肌平面阻滞对腹腔镜微创手术麻醉恢复质量的影响[J].国际麻醉学与复苏杂志,2018,39(1):13~17.
[8] 马燕,李仲然,马开喜,等.右美托咪定复合罗哌卡因腹横肌平面阻滞对老年患者结直肠癌根治术后早期恢复质量的影响[J].临床麻醉学杂志,2020,36(2):148~151.
[9] 黎贤泰,江晓敏,郑志远,等.右美托咪定对老年患者股骨头置换术后炎症因子及认知功能的影响[J].中国骨伤,2018,31(12):16~20.
[10] 张新科,司小萌,郭培霞.右美托咪定对老年病人胃癌根治术术后炎症因子及认知功能的影响[J].安徽医药,2019,23(11):2266~2270. |
|
|
|
2021, Vol. 27 
