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| Changes of Serum Vaspin and MCP-1 Levels in Patients with Coronary Heart Disease and Their Correlation with Myocardial Injury and Cardiac Function |
| JIANG Bin, CAO Limei, DONG Nengbin, et al |
| Chenzhou First People's Hospital, Hunan Chenzhou 423000, China |
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Abstract Objective: To analyze the changes of serum Vaspin and MCP-1 levels in patients with coronary heart disease and their correlation with the degree of myocardial injury and cardiac function. Methods: 120 patients with coronary heart disease admitted to our hospital from July 2017 to September 2019 were studied. According to the types of disease, they were divided into unstable angina group (71 cases) and stable angina group (49 cases). According to plaque stability, they were divided into unstable plaque group (53 cases) and stable plaque group (67 cases). According to the number of pathological changes, they were divided into single-vessel disease group (57 cases), double-vessel disease group (38 cases), and triple-vessel disease group (25 cases). In addition, 94 healthy controls in the same period were included. The serum Vaspin and MCP-1 levels were detected by enzyme linked immunosorbent assay. The differences of serum Vaspin and MCP-1 levels, myocardial injury markers and cardiac function parameters between the two groups were compared. The differences of serum Vaspin and MCP-1 levels were compared. The correlation of serum Vaspin and MCP-1 levels with myocardial injury index and cardiac function parameters in patients with coronary heart disease was analyzed. Results: The serum Vaspin level of coronary heart disease group was significantly lower than that of the control group (P<0.05), and the MCP-1 level was significantly higher than that of the control group (P<0.05). The levels of CK-MB, CK, H-FABP and cTnI in the coronary heart disease group were significantly higher than those in the control group (P<0.05). LVEF and FS in coronary heart disease group were significantly lower than those in control group (P<0.05), LVEDD and LVESD were significantly higher than those in control group (P<0.05). The serum Vaspin level in the unstable angina group was significantly lower than that in the stable angina group (P<0.05), and the MCP-1 level was significantly higher than that in the stable angina group (P<0.05). The serum Vaspin level in the unstable plaque group was significantly lower than that in the stable plaque group (P<0.05), and the MCP-1 level was significantly higher than that in the stable plaque group (P<0.05). The levels of serum Vaspin and MCP-1 were significantly higher in ripplee- vessel disease group and double-vessel disease group than in single-vessel disease group (P<0.05). The serum Vaspin level in the triple-vessel disease group was significantly lower than that in the double-vessel disease group (P<0.05), and the MCP-1 level was significantly higher than that in the double-vessel disease group (P<0.05). Serum Vaspin level was positively correlated with LVEF and FS (P<0.05), and negatively correlated with CK-MB, CK, H-FABP, cTnI, LVEDD and LVESD (P<0.05). Serum MCP-1 level was positively correlated with CK-MB, CK, H-FABP, cTnI, LVEDD and LVESD (P<0.05), and negatively correlated with LVEF and FS (P<0.05). Conclusion: The levels of serum Vaspin and MCP-1 in patients with coronary heart disease are closely related with the degree of myocardial injury and cardiac function.
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2020, Vol. 26 
