脑小血管病患者Hcy水平与认知功能障碍病程进展的相关性分析

doi:10.3969/j.issn.1006-6233.2020.12.05

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Abstract Objective: To explore the correlation between homocysteine (Hcy) level and cognitive dysfunction and disease progression in patients with small cerebral vascular disease (CSVD). Methods: A total of 78 cases of CSVD patients diagnosed and treated in our hospital from December 2016 to December 2018 were retrospectively selected as the study objects. With the Montreal cognitive assessment scale (MoCA) score, they were divided into the cognitively normal group (32 cases) and the cognitively impaired group (46 cases), and another 52 cases of healthy physical examination patients were selected as the healthy control group. The differences in clinical data and Hcy level among the three groups were compared, and the correlation between Hcy level and cognitive dysfunction and disease progression was analyzed. Results: The control group of Hcy level was (10.12±3.45) umol/L, the cognitive normal group was (18.18±3.86) umol/L, and the cognitive impairment group was (23.35±4.42) umol/L, with statistically significant differences (P<0.05). MoCA score of cognitive normal group was higher than that of cognitive impairment group, and the difference was statistically significant (P<0.05). Pearson correlation showed that Hcy level was negatively correlated with MoCA total score, visual spatial executive function, memory and attention, abstract thinking, and directional force (r=-0.438, -0.264, -0.239, -0.333, P<0.05), but not with naming, language, and delayed recall (r=-0.005, -0.001, -0.083, P>, 0.05).After a one-year follow-up, 62.82% (49/78) in the CSVD progression group and 37.18% (29/78) in the non-progression group, and Pearson correlation showed that Hcy level was significantly negatively correlated with imaging outcome scores of CSVD patients (r=-0.351,P<0.01).According to ROC curve analysis, the AUC of Hcy in predicting the course of CSVD was 0.938, the sensitivity and specificity were 87.8% and 93.1%, respectively, showing high accuracy. Conclusion: The increased level of Hcy can be involved in the cognitive impairment of CSVD, and is negatively correlated with the progression of CSVD.

Key words： Cerebrovascular disease Homocysteine Cognitive dysfunction

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	ZHANG Fu
	SUN Guixiang
	GAO Yueqiang

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ZHANG Fu,SUN Guixiang,GAO Yueqiang. Correlation Analysis of Hcy Level with Cognitive Dysfunction and Disease Progression in Patients with CSVD[J]. HeBei Med, 2020, 26(12): 1956-1960.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.12.05 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I12/1956

[1] Stefanie S, Vincent S, Valentina P, et al. Reader response: serum neurofilament light is sensitive to active cerebral small vessel disease[J]. Neurology, 2018, 90(24):1126.
[2] 范玲玲,李亚军,马姗,等.脑小血管病患者病程进展与血管内皮功能障碍因子表达水平的相关性研究[J].国际神经病学神经外科学杂志,2019,46(5):532~535.
[3] 孔花娟,韩晓敏.慢性肾病患者血清Hcy,CysC水平与认知功能障碍的相关性分析[J].现代检验医学杂志,2018,33(2):70~73.
[4] 王学颖,王洪权,赵伟丽.脑小血管病患者认知功能障碍与血尿酸、同型半胱氨酸水平相关性研究[J].神经损伤与功能重建,2019,14(7):360~361,373.
[5] 王志鹏,高仲磊,卫孟佳.脑小血管疾病磁共振成像表现与血管性认知功能障碍[J].中国临床医生杂志,2019,47(7):814~817.
[6] 卢东,徐群,赵薇,等.脑小血管病患者外周血同型半胱氨酸水平与认知功能的相关性研究[J].中国卒中杂志,2019, (2):100~105.
[7] 张丽,杨君素,朱红雯,巴瑞琼,施媛,马祥.同型半胱氨酸水平与急性缺血性脑卒中老老年患者溶栓预后相关性分析[J].河北医科大学学报,2018,39(8):872~876.
[8] 刘霞,孟云霞,孟洁,等.脑小血管病患者认知功能障碍与血浆同型半胱氨酸及胱抑素C水平的相关性[J].江苏医药,2019,45(9):886~889.
[9] 杨延芳,孙红国,江毅,等.H型高血压与脑小血管病认知功能障碍相关性研究[J].中风与神经疾病杂志,2018,35(8):715~718.
[10] 刘淑华,李福明.超声联合MRI评估颈动脉斑块易损性的二维超声回声分级与脑白质病变的关系[J].医学影像学杂志,2018,28(12):1983~1986.
[11] 叶玉冰,罗松,张龙江,等.伴有肾功能受损的系统性红斑狼疮患者脑小血管病影像学特征及其相关危险因素分析[J].中华放射学杂志,2018,52(8):575~580.