|
|
|
| The Correlations Between the Expressions of ApoB IL-18 andPostpartum Depression in Elderly Pregnant Women |
| WU Yi, et al |
| Xianyang Central Hospital, Shaanxi Xianyang 712000, China |
|
|
|
|
Abstract Objective: To explore the correlation between the expression levels of apolipoprotein B (ApoB) and interleukin-18 (IL-18) in the serum of elderly pregnant women and postpartum depression (PPD). Methods: From January 2016 to June 2019, 85 women who met the diagnostic criteria for depression were selected and followed up as required for 42 days after delivery, which was called PPD group; and 87 cases of pregnant women who did not meet the diagnostic criteria for depression during the same period of follow-up were selected for a controlled study, which was made the normal group. The general data of the two groups were compared and analyzed. The level of serum ApoB of all pregnant women was measured by immunoturbidimetry. The level of IL-18 was detected by enzyme-linked immunosorbent assay (ELISA). The Edinburgh Postpartum Depression Scale (EPDS) was used to evaluate the depression status of all pregnant women. Pearson's method was used to analyze the relationships between the levels of serum ApoB, IL-18, EPDS score and total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and the correlations between the levels of serum ApoB, IL-18 and EPDS score. And the influencing factors of PPD were analyzed by Logistic regression. Results: The levels of serum TC and HDL-C in PPD group were significantly lower than those in normal group (P<0.05), and the levels of ApoB and IL-18, and EPDS score in PPD group were significantly higher than those in normal group (P<0.05). The levels of serum ApoB and IL-18, EPDS score in PPD patients were negatively correlated with TC and HDL-C (P<0.05), and the levels of serum ApoB and IL-18 were positively correlated with EPDS score (P<0.05). TC,HDL-C levels were protective factors of PPD (P<0.05), and high levels of ApoB and IL-18 were risk factors of PPD (P<0.05). Conclusion: The expression levels of ApoB and IL-18 in serum of women with postpartum depression are up-regulated, which may be related to the degree of depressive symptoms. They may play an important role in the occurrence and development of PPD.
|
|
|
|
|
|
[1] O'HARA MW, Engeldinger J. Treatment of postpartum depression: recommendations for the clinician[J]. Clin Obstet Gynecol, 2018, 61(3):604~614.
[2] Ghaedrahmati M, Kazemi A, Kheirabadi G, et al. Postpartum depression risk factors: a narrative review[J].Educ Health Promot, 2017, 6(8):60~68.
[3] 周文慧,吴辉,谷桂珍,等.火车司机抑郁症状评分与载脂蛋白A1和B的关系[J].工业卫生与职业病,2018,44(1):3~8.
[4] 赵指亮,谢飞,范大庆,等.高龄抑郁症患者血清BDNF、SP、IL-18表达水平分析[J].国际精神病学杂志,2019,46(1):63~65.
[5] 世界卫生组织.ICD-10精神与行为障碍分类[M].北京:人民卫生出版,1995.79~80.
[6] Cox JL, Holden JM, Sagovsky R . Detection of postnatal depression: development of the 10-item edinburgh postnatal depression scale.[J]. Br Psychiatry, 1987, 150(6):782~786.
[7] Onat A, Kaya A, Ademoglu E . Modified risk associations of lipoproteins and apolipoproteins by chronic low-grade inflammation[J]. Expert Rev Cardiovasc Ther, 2017, 16(1):39~48.
[8] Steffen BT, Guan W, Remaley AT, et al. Apolipoprotein B is associated with carotid atherosclerosis progression independent of individual cholesterol measures in a 9-year prospective study of Multi-Ethnic Study of Atherosclerosis participants[J].Clin Lipidol, 2017, 11(5):1181~1191.
[9] 陈杰,王圆圆,叶海霞.帕金森病及帕金森综合征病人血脂水平的临床分析[J].中西医结合心脑血管病杂志,2017,15(9):1119~1121.
[10] Hui L, Han M, Du XD, et al. Serum ApoB levels in depressive patients: associated with cognitive deficits[J]. Sci Rep, 2017, 7(39):992~998.
[11] Bhandage AK, Cunningham JL, Jin Z, et al. Depression, GABA, and age correlate with plasma Levels of inflammatory markers[J]. Int Mol Sci, 2019, 20(24):6172~6182.
[12] Wedervang RK, Friis S, Lonning V, et al. Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms[J]. Psychoneuroendocrinology, 2020, 112(2):4513~4517. |
|
|
|
2020, Vol. 26 
