脑胶质瘤中UBE2S和CCNB1的表达及临床意义

doi:10.3969/j.issn.1006-6233.2020.11.033

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Abstract Objective: To study the expression and clinical significance of cyclin B1 (CCNB1) and ubiquitin binding enzyme E2S (UBE2S) in glioma.Methods: 106 cases of glioma tissue specimens from January 2015 to April 2019 were selected and brain glial tissue specimens from 114 patients with intracranial hemorrhage or trauma undergoing intracranial decompression were taken as control group.The expression levels of CCNB1 and UBE2S in glial tissue were measured by immunoblotting (WB).The relationships between the expression levels and clinicopathological features of glioma were analyzed.All patients were followed up.The effects of the expressions of both on the prognosis of patients with glioma were explored.Results: The expression levels of CCNB1 and UBE2S in low-grade glioma group and high-grade glioma group were significantly higher than those in the control group (P<0.05),and the expression levels of CCNB1 and UBE2S in high-grade glioma group was significantly higher than that in low-grade glioma group (P<0.05).The expression levels of CCNB1 and UBE2S in glioma tissues were not correlated with age,sex and pathological type (P>0.05),but were related to the degree of tissue differentiation,peritumoral edema and infiltration (P<0.05).Pearson analysis showed that the expression levels of CCNB1 and UBE2S in glioma tissues were positively correlated (r = 0.460,P<0.05).The median survival time of patients with high expressions of CCNB1 and UBE2S were significantly lower than those with low expressions of CCNB1 and UBE2S (P<0.05).COX multivariate analysis showed that low tissue differentiation,high expression of CCNB1 and UBE2S were independent risk factors for poor prognosis of glioma patients (P<0.05).Conclusion: The expression levels of CCNB1 and UBE2S in glioma tissues are significantly increased,which is related to the degree of differentiation,peritumoral edema,infiltration and survival time of glioma tissues,and might be a clinical index for evaluating the prognosis of glioma patients.

Key words： Glioma Cyclin B1 Ubiquitin binding enzyme E2S Prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.11.033 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I11/1906

[1] Chen M,Liu X,Xie P,et al.Circular RNA circ0074026 indicates unfavorable prognosis for patients with glioma and facilitates oncogenesis of tumor cells by targeting miR-1304 to modulate ERBB4 expression[J].Cell Physiol,2020,235(5):4688~4697.
[2] Saratchandra K,Samanthapudi VS,Penugurti V,et al.Hematopoietic PBX-interacting protein is a substrate and an inhibitor of the APC/C–CDC20 complex and regulates mitosis by stabilizing cyclin B1[J].Biol Chem,2019,294(26):10236~10252.
[3] Liu A,Zeng S,Lu X,et al.Overexpression of G2 and S phase-expressed-1 contributes to cell proliferation,migration,and invasion via regulating p53/FoxM1/CCNB1 pathway and predicts poor prognosis in bladder cancer[J].Int Biol Macromol,2019,123(1):322~334.
[4] Lin M,Lei T,Zheng J,et al.UBE2S mediates tumor progression via SOX6/β-Catenin signaling in endometrial cancer[J].Int Biochem Cell B,2019,109(1):17~22.
[5] Martinez-Lage M,Sahm F.Practical implications of the updated WHO classification of brain tumors[J].Semin Neurol,2018,38(1):11~18.
[6] Cui XL,Wang XD,Lin SK,et al.Circular RNA circ0067934 functions as an oncogene in glioma by targeting CSF1[J].Eur Rev Med Pharmaco,2019,23(19):8449~8455.
[7] Lim-Fat MJ,Nayak L,Meredith DM,et al.Genomic biomarker assessment in gliomas[J].Surg Pathol Clin,2020,13(2):209~215.
[8] Wang S,Sun H,Zhan X,et al.MicroRNA-718 serves a tumor-suppressive role in non-small cell lung cancer by directly targeting CCNB1[J].Int Mol Med,2020,45(1):33~44.
[9] Fei F,Qu J,Liu K,et al.The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance[J].Lab Invest,2019,99(4):483~498.
[10] 王玲,范文葛,毛敏.CyclinA和CyclinB1在乳房外Paget病中的表达及意义[J].中国中西医结合皮肤性病学杂志,2017,16(6):489~490.
[11] Ding L,Yang L,He Y,et al.CREPT/RPRD1B associates with aurora B to regulate cyclin B1 expression for accelerating the G2/M transition in gastric cancer[J].Cell Death Dis,2018,9(12):131~149.
[12] 胡力,沈红,刘利,等.Akt1通过磷酸化泛素结合酶E2S增强胶质瘤放化疗抵抗的实验研究[J].中华神经外科杂志,2018,34(2):194~199.
[13] 曹进,张景涛,刘中砚,等.泛素结合酶E2s在胆囊癌患者中的高表达及意义[J].中华实验外科杂志,2018,35(7):1321~1324.