阿奇霉素联合养阴清肺汤对支气管肺炎患儿血清IL-1β和TNF-α表达的影响

doi:10.3969/j.issn.1006-6233.2020.11.029

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Abstract Objective: To study the curative effect of Azithromycin combined with Yangyinqingfei Decoction on the serum interleukin-1beta (IL-1 beta) and tumor necrosis factor alpha (TNF- alpha) expressions of children with bronchial pneumonia.Methods: 96 cases of children with bronchial pneumonia in our hospital from October 2015 to December 2016 were randomly divided into the control group and the observation group with 48 cases in each group.The control group was administered azithromycin treatment,and the observation group was treated by oral Yangyinqingfei decoction on the basis of control group.The total effective rate,disappearance time of clinical symptoms and signs and changes of serum IL-1 and beta TNF- alpha levels before and after treatment were compared between two groups.Results: After treatment,the total efficiency of observation group (93.75%) was significantly higher than the control group (77.08%) (P=0.02);The disappearance time of fever,cough,pulmonary rales,pulmonary shadow and hospital stay of observation group were significantly shorter than those of the control group(P<0.01);The serum IL-1 beta and TNF- levels of observation group were significantly lower than those of the control group(P<0.01).Conclusion: the Azithromycin combined with Yangyinqingfei Decoction could enhance the clinical efficacy in the treatment of children with bronchial pneumonia,which was able to promote the recovery of the symptoms and signs,decrease the serum IL-1 beta and TNF- levels.

Key words： Azithromycin Yangyin qingfei decoction Bronchial pneumonia IL-1 TNF-α

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.11.029 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I11/1886

[1] 程秀芳,陈俊松.肺炎支原体感染对支气管哮喘病儿外周血1、9、17型辅助性T细胞及相关细胞因子水平的影响[J].安徽医药,2019,23(6):1210~1213.
[2] 张晗,尚云晓.纤维支气管镜对儿童难治性肺炎支原体肺炎的诊断治疗价值[J].中国实用儿科杂志,2019,34(6):504~507.
[3] Bilal MS,Ozyuksel A,Avsar MK,et al.Urgent double switch operation in a patient with congenitally corrected transposition of great arteries and an untrained systemic ventricle[J].Turk Gogus Kalp Damar Cerrahisi Derg,2020,28(1):197~200.
[4] 高振华.支气管肺炎的诊断[J].山东医药,2008,48(44):103~104.
[5] 《抗菌药物临床试验技术指导原则》写作组.抗菌药物临床试验技术指导原则[J].中国临床药理学杂志,2014,30(9):844~856.
[6] 方芳,蔡成思.加味桔梗汤合保和丸治疗小儿支气管肺炎的临床研究[J].中药材,2018,41(7):1754~1756.
[7] 易茜,吴毅,李媛媛,等.肺炎支原体肺炎闭塞性支气管炎1例报告并文献复习[J].临床儿科杂志,2019,37(6):423~426.
[8] Haryanto B.Indonesia:country report on children's environmental health[J].Rev Environ Health,2020,35(1):41~48.
[9] 谭志平,陈观尚,黄霞.热毒宁注射液联合纤维支气管肺泡灌洗吸痰对重症肺炎患者血T淋巴细胞亚群及预后的影响[J].广州中医药大学学报,2019,36(10):1520~1526.
[10] 李明珠,金圣博.养阴清肺汤联合美洲大蠊研末治疗30例鼻咽癌患者放疗后急性放射性口腔黏膜炎的临床疗效[J].华西药学杂志,2018,33(5):570~572.
[11] 夏建鸿,牛丽丽,潘东续,等.血必净联合清肺养阴汤对慢性阻塞性肺疾病急性加重期患者炎性反应及抗氧化能力的影响[J].现代中西医结合杂志,2019,28(23):2537~2540,2583.
[12] Obiora UJ,Ekpebe PA,Okoye C,et al.Audit of childhood death in a tertiary care center in niger delta region of nigeria[J].West Afr Med,2020,37(2):113~117.