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| Effects of Paroxib Sodium Combined with Dexmedetomidine on Stress Hormone Levels and OAA/S Sedation Scores After Hip Replacement in Elderly patients |
| LU Haibo, LIAO Xingzhi, SHI Dongdong |
| 904 Hospital of the Joint Service Support Force of the PLA,Jiangsu Wuxi 214000,China |
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Abstract Objective: Analysis of the effect of paroxib sodium combined with dexmedetomidine on stress hormone levels and OAA/S sedation scores after hip replacement in the elderly.Methods: From June 2018 to February 2020,184 elderly patients who underwent unilateral hip replacement were divided into observation group and control group by random number table method.Dexmedetomidine was administered in the control group and paroxib sodium combined with dexmedetomidine was administered in the observation group.The VAS scores of the two groups were observed at different time after operation.At the same time,the levels of postoperative stress index (superoxide dismutase- SOD、 malondialdehyde- MDA) and OAA/S sedation scores were compared between the two groups.Finally,the incidence of adverse reactions between the two groups was counted.Results: The interaction effects between time points,between groups,between time points and groups of VAS scores in the two groups were statistically significant (P<0.05).The 6 h VAS、12h VAS、24h VAS scores of observation group and control group were significantly lower than those of control group (P<0.05).There was significant difference in the SOD、MDA、OAA/S sedation score between the observation group and the control group after 1 d (P<0.05).Adverse reaction rate in observation group was significantly lower than that in control group (P<0.05).Conclusion: The application of paroxib sodium combined with dexmedetomidine for advanced analgesia in elderly patients with hip arthroplasty can effectively reduce the postoperative pain score thus improve the postoperative stress response status of patients,and help to improve the sedation effect,which is worth popularizing.
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2020, Vol. 26 
