小剂量低分子肝素钙治疗脓毒症患儿临床疗效及安全性评价

doi:10.3969/j.issn.1006-6233.2017.10.044

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Abstract Objective: To evaluate the curative efficacy and safety of small dose of low-molecular-weight heparin calcium for the treatment of children with sepsis. Methods: 92 cases of children with sepsis were randomly divided into control group(46 cases) and experiment group(46 cases). Patients in both groups were given oxygen, anti-infection, treatment of the original disease and other conventional treatment. According to the control group, patients in the experiment group were given low molecular weight heparin calcium at 10 IU/kg every 12 hours by subcutaneous injection. After treatment, coagulation function and clinical curative effect were compared. Results: The total clinical efficacy of the treatment group (95.65%) was significantly higher than that of the control group (69.57%), the difference was statistically significant (P<0.05). After treatment, the PT, TT and APTT in 2 groups were slightly decreased, but not statistically different (P<0.05). The APTT, PT and TT in patients of the treatment group were significantly lower than that in the control group (P<0.05). The FIB levels were significantly increased with time and the values in experiment group were significantly higher than that in control group (P<0.05). There was no significant difference in adverse reactions between the two groups (P > 0.05). Conclusion: Small dose of low molecular weight heparin calcium can improve the clinical treatment efficacy, improve the coagulation function in children with sepsis.

Key words： Heparin calcium Coagulation function Sepsis Curative efficacy

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.10.044 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I10/1732

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