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| The Relationship Between HSP70 TNF-α IL-4 and Humoral Immunity of Hypertensive Patients During Pregnancy |
| WANG Ying, HONG Haiman, MENG Fei |
| The Affiliated Central Hospital of Shenyang Medical College,Liaoning Shenyang 110024,China |
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Abstract Objective: To analyze the relationship between heat shock 70 KDa protein (HSP70),tumor necrosis factor-α(tnf-),interleukin-4(IL-4) and humoral immunity in hypertensive patients during pregnancy.Methods: 108 patients with gestational hypertension treated in hospitals from December 2016 to June 2019 were selected as observation group,and 108 pregnant women in the same period,the control group.Observe the humoral immune indexes and serum HSP70,TNF-α,IL-4 differences between the two groups,and to analyze the correlation between HSP70,TNF-α,IL-4 and humoral immunity in hypertensive patients during pregnancy.Results: There was significant difference in humoral immunity between observation group and control group (P<0.05).There was significant difference in serum HSP70,TNF-α and IL-4 levels between the observation group and the control group (P<0.05).The correlation analysis showed that there was a close correlation between HSP70,TNF-α,IL-4 and humoral immunity in patients with gestational hypertension (all P<0.05).Conclusion: There is a positive correlation between humoral immune level and HSP70,TNF-α,IL-4 in hypertensive patients during pregnancy,which can screen high-risk pregnant women through HSP70,TNF-α,IL-4 examination,so as to give effective intervention measures as soon as possible to protect the health and safety of mother and child.
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[1] Martell C N.Gestational hypertension[J].Hypertension Y Riesgo Vascular,2017,34 (Suppl 2):22.
[2] 王玲,华扬.彩色多普勒超声监测妊娠高血压综合症对肾脏及子宫胎盘血液循环的影响[J].河北医学,2017,23(9):1415~1419.
[3] 孙文平,刘洪梅.血清钙25-(OH)D3碱性磷酸酶与妊娠期高血压疾病的相关性研究进展[J].安徽医学,2018,39(2):245~246.
[4] Galbraith G M,Steed R B,Sanders J J,et al.Tumor necrosis factor alpha production by oral leukocytes:influence of tumor necrosis factor genotype.[J].Journal of Periodontology,2017,69(4):428~433.
[5] Vulpen L F D V,Popov-Celeketic J,Meegeren M E R V,et al.A fusion protein of interleukin-4 and interleukin-10 protects against blood-induced cartilage damage in vitro and in vivo[J].Journal of Thrombosis &Haemostasis,2017,15(9):S505~S505.
[6] 蓝永洪,饶朗毓,杨智,等.妊娠高血压综合征患者胎盘组织中HIF-1α和HSP70的表达及其意义[J].吉林大学学报(医学版),2018,44(2):346~349.
[7] 海长娥,王丽萍.HPA、MMP-9、AGEs、RAGE及HSP70在妊娠期高血压患者血清及胎盘中的表达分析[J].河北医药,2019,41(5):752~755.
[8] 徐东魁,禹晓冰,高芳.血清肿瘤坏死因子-α和游离雌三醇水平在妊娠高血压患者中的表达及临床意义[J].解放军医药杂志,2019,31(9):69~72.
[9] 李萍,张丽,黄柳琴.糜烂性胃炎幽门螺杆菌阳性患者益生菌联合四联疗法治疗后胃肠道微生态变化观察[J].现代消化及介入诊疗,2019,24(9):961~964,968. |
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2020, Vol. 26 
