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| Curative Effect of Sulperazone Combined with Ambroxol on Neonatal Infectious Pneumonia and Their Influences on Immunity |
| SU Lina, LI Wenlin, CHEN Caihua, et al |
| Pediatrics Department, Women and Children's Medical Center,Hainan Haikou 570100, China |
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Abstract Objective: To observe the clinical curative effect of sulperazone combined with ambroxol hydrochloride on neonatal infectious pneumonia, and to explore their influences on respiratory flora and immune status. Methods: The clinical case data of 98 neonates with infectious pneumonia who were admitted to the hospital from October 2017 to October 2019 were retrospectively analyzed. According to different medication methods, they were divided into control group (n=46) and combination group (n=52). The control group was given sulperazone for anti-infective treatment on basis of routine oxygen inhalation and nutritional support, while combination group was given ambroxol hydrochloride for aerosol inhalation on basis of control group. The clinical curative effect, changes in arterial oxygen partial pressure (PaO2) and arterial partial pressure of carbon dioxide (PaCO2), disappearance time of clinical symptoms, length of hospital stay, immunoglobulin (IG) level and adverse reactions were compared between the two groups. Results: The total response rate in combination group was higher than that in control group (P<0.05). After treatment, level of PaO2 was increased in both groups, and the combination group had larger rangeability than control group (P<0.05). After treatment, level of PaCO2 was decreased in both groups, and the combination group had larger rangeability than control group (P<0.05). The disappearance time of asthma and lung signs in combination group were earlier than that in control group, and hospital stay was significantly shorter than that in control group (P<0.05). After treatment, levels of IgM, IgA, and IgG in combination group were higher than those in control group (P<0.05). There was no significant difference in total incidence of adverse reactions between the two groups (P>0.05). Conclusion: The curative effect of sulperazone combined with ambroxol hydrochloride for aerosol inhalation neonatal is significant on neonatal pneumonia. It can effectively improve arterial blood gas, promote disappearance of clinical symptoms, and shorten the course of disease.
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2020, Vol. 26 
