|
|
|
| The Establishment and Clinical Value of Medians of Serum Markers in Down's Syndrome Prenatal Screening |
| MI Dongqing, SONG Ge, PENG Yuanyuan, et al |
| The Fourth Hospital of Shijiazhuang, Hebei Shijiazhuang 050011, China |
|
|
|
|
Abstract Objective: To establish the median equation of serum markers in prenatal screening in the early and middle pregnancy in Shijiazhuang area and explore the screening efficiency and clinical value of the localized median equation. Methods: We collected the screening data of the 28930 pregnant women in the first and second trimester from January 2017 to November 2018. The median values of PAPP-A, free hCGβ, AFP, uE3 and NT in both the software record and in local population were compared. Then the data were applied to the evaluation of the risk of Down's syndrome and compared the difference of the screening efficiency. Results: 1. The median concentrations of PAPP-A, free hCGβ, uE3 in Shijiazhuang were higher than those of Caucasian population. The difference was statistically significant(P<0.05). There was no significant difference in the median concentration of AFP between the local population and the Caucasian population(P>0.05). 2. There were significant differences between the MoM median of serum markers of local population and software median equation (P<0.05). 3. By using the median of local population, the high-risk rate of trisomy 21 was 2.33%. The detection rate of trisomy 21 was 94.59%. By using the software's built-in median, the high-risk rate of trisomy 21 was 2.16%. The detection rate of trisomy 21 was 86.48%. The difference was statistically significant(P<0.05). Conclusion: The medians of serum markers were significantly different between the population of Shijiazhuang and the Caucasus population. The application of the localized median can significantly improve the screening efficiency. For the development of Down's screening in Shijiazhuang, it is of great significance to establish the localized median database of serums markers in the first and second trimester of pregnancy.
|
|
|
|
|
|
[1] Al-Nbaheen MS. Analysis of downs syndrome with molecular techniques for future diagnoses[J]. Saudi Biol Sci,2018,25(3):558~562.
[2] 陈益明,卢莎,张闻,等.杭州市胎儿18三体综合征发生率及相关因素分析[J].预防医学,2018,30(12):1284~1287.
[3] 杨岚,石皓,赵丽,等.无锡地区孕中期孕妇血清AFP、freeβ-HCG、uE3中位数标化及其应用[J].山东医药,2017,57(3):1~4.
[4] 许晓红,刘纪君.中孕期二联和三联血清学产前筛查效率的比对分析[J].临床输血与检验,2019,21(5):506~510.
[5] 刘舲,杜起军,王玲玲.胎儿NT超声联合血清学指标检测在孕早期胎儿染色体异常产前筛查中的应用价值[J].中国医师杂志,2017,19(3):429~431.
[6] Bestwick JP, Wald NJ.Sequential integrated antenatal screening for down's syndrome, trisomy 18 and trisomy 13[J].Med Screen,2016,23(3):116~123.
[7] 唐斌,陈柯艺,钟志成,等.孕早中期阶段性序贯唐氏综合征血清学筛查的效果分析[J].中国产前诊断杂志(电子版),2018,10(2):8~12.
[8] 李冬秀,吴学威,黄湘,等.中山市孕中期产前筛查指标中位数的建立及临床价值研究[J].分子诊断与治疗杂志,2018,10(4):278~282.
[9] 何法霖,王薇,钟堃,等.2015年全国中孕期母血清产前筛查相关指标的调查与分析[J].现代检验医学杂志,2017,32(1):154~156,164.
[10] 高刚,林晓杰,张力等.孕早中期产前筛查血清标志物中位数的研究[J].国际遗传学杂志,2019,41(2):120~123.
[11] 龙耀,刘艳秋,马鹏鹏,等.江西省中北部地区孕中期唐氏综合征筛查血清标志物中位数的构建[J].中南大学学报(医学版),2017,42(7):831~835.
[12] 周洪亮,郭克建,张健,等.济宁地区孕中期孕妇血清学筛查指标中位数库的建立[J].济宁医学院学报,2019,42(4):267~270,278. |
|
|
|
2020, Vol. 26 
