|
|
Clinical Study on the Correlation between High Positive Rate of HBsAg and Vaccination in Children |
AN Hebing, MA Yuanyuan, et al |
The Second Affiliated Hospital of Hebei North University, Hebei Zhangjiakou 075100, China |
|
|
Abstract Objective: Through the statistical study on the detection of HBsAg in 0~1 year-old infants within 2 weeks after vaccination, the positive rate was close to 10%. To analyze whether the low titer of HBsAg was positive and the positive rate was relatively high, whether it was related to vaccination, and to explore its mechanism and clinical significance. Methods: Children aged 0~1 years who were vaccinated with hepatitis B vaccine in pediatric ward and immune clinic from 2016 to 2019 were selected. The serum samples of 193 cases with low HBsAg titer positive were detected by chemiluminescent microparticle method within 2 weeks after vaccination. The same detection method was used to retest the HBsAg of these 193 infants aged 0~1 years after half a year, and the positive rate was counted After the vaccine was diluted with different concentrations, the same detection method was used to detect HBsAg, the dilution multiple of positive results was counted, and then the concentration of vaccine in different stages of infants was calculated by intramuscular injection, and the detection results of different types were statistically analyzed. Results: In 193 infants, HBsAg was re-examined half a year later. Four cases were positive, with a positive rate of only 2.1%, indicating that the low titer of HBsAg detected within 2 weeks in 0~1 year old infants with hepatitis b vaccine was directly related to vaccination, and the difference was statistically significant (P<0.05) , HBsAg vaccine in different concentration, test results and vaccines in the different stages of infant concentration analysis of vaccine to dilute concentration in the body should be characterized by negative result, the cause of the high positive rate and low HBsAg drops degrees may be related to stimulate the body to produce the vaccine immune effect, the difference have statistical word meaning (p<0.05). Conclusion: the hepatitis b vaccine inoculation of 0 and 1 years old infants and young children appear HBsAg. Low-grade high positive rate and correlated with vaccination, most of the infants and young children for half a year after testing HBsAg, overcast, there are a few not may be cloudy and vaccination has nothing to do, is once infected with HBV became second liver carrier, through above research and analysis, can provide theoretical basis for the doctor to the clinical diagnosis of whether children are infected with second liver.
|
|
|
|
|
[1] 徐志伟,武成奇,楚亦文,等.新生儿接种乙肝疫苗后无(弱)应答情况及其影响因素研究[J].现代预防医学,2016,43(21):4015~4018,4023. [2] 牛新海.乙肝疫苗联合乙肝免疫球蛋白阻断乙肝病毒传播的临床应用评价[J].国际检验医学杂志,2015,36(4):538~540. [3] 丁自军,余小冰,管菜英,等.乙肝疫苗接种控制儿童乙肝感染的效果研究[J].世界临床医学,2016,10(15):158~162. [4] 张丽,陈波.新生儿乙肝疫苗接种对乙肝病毒表面抗原阳性率的影响[J].临床检验杂志,2016,5(4):202~204. [5] 袁强,杨亚波.乙肝疫苗接种在控制儿童乙肝感染中的价值分析[J].养生保健指南,2016,7(33):17,71. [6] 刘华,王颖智,沈云岳,等.乙肝疫苗接种后新生儿乙型肝炎表面抗原一过性阳性的研究[J].检验医学,2015,30(11):1107~1112. [7] 黎洁莹.乙型肝炎疫苗免疫接种对新生儿的临床效果观察[J].中国医药科学,2018,1(8):244~246. [8] 周红星,江应安.乙型肝炎病毒表面抗原在慢性乙型肝炎病毒感染后不同临床阶段的定量检测及临床意义[J].中国医师进修杂志,2014,37(24):20~24. [9] 沈彦,陈永健,周永列,等.新生儿乙肝疫苗接种对乙肝表面抗原即时检测结果的影响[J].浙江预防医学,2015,8(7):738~740. [10] 杜诺.实时荧光定量PCR法检测乙肝病毒与研究[J].中国现代药物应用,2017,11(1):55~56. |
|
|
|