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| Expression of DJ-1 in Prostate Cancer and its Relationship with Curative Effect of Neoadjuvant Endocrine Therapy |
| WEI Gaomeng, TANG Yujin, HUANG Yongping |
| The Affiliated Hospital of Youjiang Medical College for Nationalities, Guangxi Baise 533000, China |
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Abstract Objective: To explore the expression of DJ-1 in prostate cancer and its relationship with curative effect of neoadjuvant endocrine therapy. Methods: The cancer tissues and para-cancerous fresh tissues of 98 patients who were confirmed with prostate cancer by puncture in the hospital from January 2015 to April 2016 were collected. The paraffin blocks of benign prostatic hyperplasia (BPH) tissues from 98 BPH patients were collected. The expression level of DJ-1 protein in each tissue was detected by immunohistochemistry. The expression level of DJ-1 protein in prostate cancer patients before and after neoadjuvant endocrine therapy was detected. χ2 test was applied to analyze the relationship between DJ-1 and clinical pathological parameters of prostate cancer, curative effect of neoadjuvant endocrine therapy. Kaplan-Meier survival curve and Log-rank method were applied to detect the relationship between DJ-1 and biochemical recurrence-free survival (BRFS). Results: The expression level of DJ-1 protein in BPH tissues was significantly lower than that in prostatic cancer tissues (P<0.05). There was no significant difference in the above index between BPH tissues and para-cancerous tissues (P>0.05). The expression level of DJ-1 protein in para-cancerous tissues was significantly lower than that in prostatic cancer tissues (P<0.05). After neoadjuvant endocrine therapy, positive expression of DJ-1 was decreased (P<0.05). There were significant differences in Gleason staging, lymph node metastasis, TNM staging and clinical curative effect between patients with positive DJ-1 and negative DJ-1 (P<0.05). The 3-year BRFS rates in DJ-1 negative (-), weak positive (+), moderate positive (++) and strong positive (+++) group were 93.33%, 87.50%, 74.07% and 70.27%, respectively. The differences among all groups were statistically significant detected by Log-rank test (P<0.05). Conclusion: The expression of DJ-1 is associated with tumor differentiation, lymph node metastasis, TNM staging, clinical curative effect of neoadjuvant endocrine therapy and 3-year BRFS rate, which is of certain predictive value for prognosis of patients with prostate cancer.
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2020, Vol. 26 
