AP-2α ITGB1在宫颈鳞癌中的表达及与预后的相关性分析

doi:10.3969/j.issn.1006-6233.2020.10.006

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Abstract Objective: To analyze the relationships between AP-2α and ITGB1 expressions and prognosis of cervical squamous cell carcinoma. Methods: 93 cases of cervical squamous cell carcinoma were selected from October 2013 to December 2016 in our hospital, and 93 cases of hysteromyoma patients who needed total hysterectomy at the same time were selected as control. Cervical squamous cell carcinoma and normal cervical tissue were collected during operation, the expression levels of AP-2α and ITGB1 were detected by immunohistochemical staining, the relationship between the two levels and clinicopathological features, prognosis of cervical squamous cell carcinoma were analyzed, and Cox regression model was used to analyze the risk factors of adverse prognosis in patients with cervical squamous cell carcinoma. Results: The positive expression rate of AP-2α protein in cervical squamous cell carcinoma was significantly lower than that in normal cervical tissue, and the positive expression rate of ITGB1 protein was significantly higher than that in normal cervical tissue (P<0.05). The expression levels of AP-2α and ITGB1 were correlated with myometrial invasion, FIGO stage and lymph node metastasis (P<0.05). There was a negative correlation between AP-2α and ITGB1 expressions in cervical squamous cell carcinoma (r=-0.582, P<0.05). The 3-year overall survival rate of AP-2α positive group was significantly higher than that of AP-2α negative group, and the 3-year overall survival rate of ITGB1 positive group was significantly lower than that of ITGB1 negative group (P<0.05). FIGO stage III, lymph node metastasis, AP-2α negative and ITGB1 positive were independent risk factors for adverse prognosis of cervical squamous cell carcinoma (all P<0.05). Conclusion: Compared with normal cervical tissues, the expression of AP-2α in cervical squamous cell carcinoma is decreased, the expression of ITGB1 is increased. Both of them are associated with myometrial invasion, FIGO staging, lymph node metastasis and survival rate of patients with cervical squamous cell carcinoma. They are independent risk factors for adverse prognosis of patients with cervical squamous cell carcinoma. They may be used as markers for prognosis evaluation.

Key words： Transcription factor activator protein-2α Integrin β-1 protein Cervical squamous cell carcinoma

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.10.006 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I10/1608

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