早期序贯性血液灌流联合糖皮质激素治疗急性蜂蜇伤横纹肌溶解症的疗效观察

doi:10.3969/j.issn.1006-6233.2020.09.034

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Abstract Objective: To observe the effectiveness of early sequential hemoperfusion (HP) combined with glucocorticoid in the treatment of acute rhabdomyolysis (RM) with bee stings.Methods: A total of 108 patients with RM with bee stings in our hospital from May 2017 to October 2019 were selected and evenly divided into control group and study group with the simple random number table method.Patients in control group had the conventional treatment plus early sequential HP, and patients in study group had glucocorticoid on the basis of control group.The biochemical indicators [creatine kinase (CK), myoglobin (Myo), serum creatinine (SCr), blood urine nitrogen (BUN)], inflammatory indicators [tumor necrosis factor (TNF-α), interleukin-6 (IL-6), procalcitonin (PCT)] and disease status (APACHEⅡ score) were compared between the two groups before treatment and 72h after treatment, and the prognosis status [hospital stay, Acute Kidney Injury stage 3 (AKI stage 3), Multiple Organ Dysfunction Syndrome (MODS) and occurrence of mortality] were recorded.Results: 72h after treatment, the levels of CK, Myo, SCr, BUN, TNF-α, IL-6 and PCT and APACHEⅡ score in the two groups were significantly decreased compared with those before treatment (P<0.05), and there were statistically significant differences in the above indexes in study group compared with those in control group (P<0.05).The hospital stay, incidence rate of AKI stage 3, incidence rate of MODS and mortality rate in study group were significantly lower than those in control group (P<0.05).Conclusion: For patients of acute rhabdomyolysis with acute bee stings, early sequential hemoperfusion combined with glucocorticoid has significant curative effects, and it can significantly improve biochemical indicators, reduce inflammatory response, and improve prognosis, with good application value.

Key words： Bee stings Acute rhabdomyolysis Sequential hemoperfusion Glucocorticoid

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.09.034 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I9/1551

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