|
|
|
| The Analysis of the Effects of Lanthanum Carbonate on Calcium and Phosphorus Levels and Its Safety in Patients Undergoing Maintenance Hemodialysis |
| WU Dan, LIU Shengyang, REN Lili |
| Liaoyang Central Hospital, Liaoning Liaoyang 111000, China |
|
|
|
|
Abstract Objective: To analyze the effects and safety of lanthanum carbonate in improving calcium and phosphorus levels in patients undergoing maintenance hemodialysis.Methods: A total of 92 patients who were expecting maintenance hemodialysis were divided into control group (n=46) and treatment group (n=46) with the simple random grouping method.Control group was treated with calcium carbonate, and treatment group was treated with lanthanum carbonate.After 2 months of treatment, levels of blood calcium, blood phosphorus, intact parathyroid hormone (iPTH) and serum 25-hydroxyvitamin D (25OHD) and changes of vascular endothelial function were compared between the two groups.Safety was evaluated.Results: There were no obvious changes in levels of blood calcium or iPTH before and after treatment (P>0.05), but blood phosphorus level was significantly decreased after treatment (P<0.05).The pre- and post-operative differences of blood calcium level and blood phosphorus level in treatment group were obviously greater than those in control group (P<0.05), but the pre- and post-operative difference of iPTH of the two groups was not statistically significant (P>0.05).The serum 25OHD level in treatment group was significantly increased after treatment (P<0.05), but there was no significant change in control group (P>0.05).The pre- and post-operative difference of serum 25OHD level in treatment group was greater than that in control group (P<0.05).The flow-mediated dilation (FMD) in treatment group was significantly increased after treatment (P<0.05) while the fibroblast growth factor-23 (FGF23) was significantly decreased after treatment (P<0.05).There were no obvious changes in FMD or FGF23 in control group before and after treatment (P>0.05).The pre- and post-operative differences of FMD and FGF23 in treatment group were greater than those in control group (P<0.05).At 1 week after the end of treatment, the review results of blood, liver and kidney function and electrocardiogram in the two groups were in normal range.There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).Conclusion: Effects of lanthanum carbonate are more obvious than calcium carbonate in the treatment of patients undergoing maintenance hemodialysis.The former can significantly reduce the blood phosphorus level, increase the serum 25OHD level and improve the vascular endothelial function, without causing changes in blood calcium level and with high safety.
|
|
|
|
|
|
[1] 朱亚林,薛贵方,熊晓红,等.维持性血液透析患者精神心理状况分析及其与神经营养因子水平的相关性研究[J].检验医学与临床,2017,14(4):135~137.
[2] 刘倩,孟晓燕,罗春明,等.维持性血液透析患者血管钙化与维生素K2摄入关系的研究[J].中国医药导报,2017,14(6):88~91.
[3] 王婷,毕伟红.醋酸钙治疗维持性血液透析患者高磷血症的临床研究[J].中国医药指南,2017,15(11):37~38.
[4] 许涛,崔勇平,俞岗,等.碳酸镧纠正糖尿病肾病维持性血液透析患者钙磷代谢紊乱1例[J].中国血液净化,2017,16(11):789~791.
[5] 赵飞,任野平,孔凡武.慢性肾脏病患者交感神经系统及肾素-血管紧张素-醛固酮系统与肾脏疾病进展之间的关系[J].中华老年多器官疾病杂志,2017,16(5):394~397.
[6] 邓菲,冯静,李怡,等.碳酸镧对维持性血液透析患者高磷血症的疗效及安全性[J].实用药物与临床,2017,20(4):398~401.
[7] Zhang C , Wang S , Zhao S , et al. Effect of lanthanum carbonate on coronary artery calcification and bone mineral density in maintenance hemodialysis patients with diabetes complicated with adynamic bone disease: a prospective pilot study[J]. medicine, 2017,96(45):e8664.
[8] 郭丛丛,彭艳梅,张亚芹,等.肱动脉血流介导的内皮依赖性舒张功能的变化对冠状动脉病变的预测价值[J].中国动脉硬化杂志,2018,26(7):715~719.
[9] 蔡震川,李培贵,张万军,等.碳酸镧与醋酸钙治疗维持性透析患者高磷血症的对比研究[J].实用医院临床杂志,2018,15(3):183~186. |
|
|
|
2020, Vol. 26 
