复方黄柏液联合派瑞松对脂溢性皮炎患者皮肤组织K17和静脉血清IL-2 IL-8水平的影响

doi:10.3969/j.issn.1006-6233.2017.10.038

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Abstract Objective: To investigate the effects of compound huang bai liquid combined with pevisone on the expression levels of skin tissue K17 and serum IL - 2, IL - 8 in patients with seborrheic dermatitis. Methods: 130 patients with seborrheic dermatitis from our hospital were analyzed by retrospective study, and they were divided into experiment group and control group by random number table, 65 cases in each group. Patients in the control group were only given pevisone; While, patients in the experiment group were treated by compound huang bai liquid combined with pevisone. After treatment, the expression levels of skin tissue K17 and serum interleukin 2 (IL - 2), interleukin 8 (IL - 8) levels, the adverse reactions and the clinical efficiency in patients of the two groups patients were compared. Results: Compared with before treatment, the expression levels of skin tissue K17 in patients of the two groups were significantly decreased; The expression levels of serum IL - 2 and IL - 8 significantly increased (P < 0.05); Compared with the control group, the expression level of K17 in the experiment group was lower (P < 0.05), but the serum levels of IL - 2 and IL - 8 were higher (P < 0.05). The incidence rate of adverse reactions in experiment group were significantly lower than that in control group (P < 0.05). The clinical efficacy was significantly higher in experiment group than that in control group (P < 0.05). Conclusion: Compound huang bai liquid combine with pevisone in the treatment of patients with seborrheic dermatitis has good clinical efficacy, and could significantly reduce the incidence rate of adverse reactions. We speculate that the mechanism maybe related to the decline of the expression levels of K17 and increasing the serum IL - 2 and IL - 8 levels.

Key words： Compound huang bai liquid Pevisone Seborrheic dermatitis K17 IL - 2 IL - 8

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