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| Effects of High-Dose Ambroxol Hydrochloride Combined with Fiberbronchoscope Lavage on Oxygenation Index Serum CRP and PCT Levels in Elderly Patients with Severe Pneumonia |
| CHEN Miancong, CHEN Wei, LIN Xiushan, et al |
| The First Affiliated Hospital of Hainan Medical College, Hainan Haikou 570102, China |
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Abstract Objective: To explore the fiberbronchoscope value of high-dose ambroxol hydrochloride combined with fiberbronchoscope lavage in elderly patients with severe pneumonia (SP).Methods: 90 elderly patients with SP treated in the hospital between July 2016 and July 2019 were divided into the single medication group and the combined medication group with the computer-assisted random number method.They were treated with high-dose ambroxol hydrochloride and high-dose ambroxol hydrochloride combined with bronchoscopic lavage, respectively.The curative effect and related indicators in the two groups were evaluated.Results: The total effective rate of treatment in the combined medication group (97.78%) was significantly higher than that in the single medication group (82.22%)(P<0.05).The arterial partial pressure of oxygen (PaO2), degree of blood oxygen saturation (SaO2) and oxygenation indexes in the two groups increased significantly after treatment (P<0.05), while levels of C-reactive protein (CRP) and procalcitonin (PCT) decreased significantly (P<0.05).The increase or decrease in the combined medication group was significantly greater than that in the single medication group (P<0.05).The APACHE Ⅱ score, duration of mechanical ventilation, lung symptom disappearance time and length of intensive care unit (ICU) stay of the combined medication group after treatment were significantly lower or shorter than those of the single medication group (P<0.05).The incidence rate of multiple organ failure (MOF) and 28-day mortality rate in the combined medication group (15.56% and 6.67%) were significantly lower than those in the single medication group (37.78% and 24.44%)(P<0.05).Conclusion: High-dose ambroxol hydrochloride combined with bronchoscopic lavage is effective in the treatment of elderly SP.It can obviously improve the oxygenation index, improve the condition, and reduce inflammation and mortality rate.
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2020, Vol. 26 
