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| Effects of Propofol Combined with Remifentanil on Hemodynamics and Brain Cell Function in Patients with Emergency Craniocerebral Injury |
| GAO Sanjie, ZHANG Xianjie, XIA Leqiang, et al |
| Deyang People's Hospital, Sichuan Deyang 618000, China |
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Abstract Objective: To investigate the effects of propofol combined with remifentanil on hemodynamics and brain cell function in patients with emergency craniocerebral injury. Methods: 64 patients with emergency craniocerebral injury surgery in our hospital from March 2018 to September 2019 were selected as the research objects. The subjects were randomly divided into study group and control group, 32 cases in each group. The control group used remifentanil anesthesia during the operation, and the study group used propofol and remifentanil anesthesia. The hemodynamic levels and brain cell function indexes of the two groups were observed and compared before operation (T0), 1 hour after anesthesia (T1), at the end of operation (T2), and 2 hours after operation (T3). Results: There were no significant differences in the levels of SBP, DBP, NSE and MBP between the two groups before surgery (P>0.05). At 1 h after anesthesia and at the end of the operation, the SBP and DBP of the two groups were lower than those before the operation, while the NSE and MBP levels were higher than the preoperative ones, and the difference was statistically significant (P<0.05). At 2 h after operation, the SBP, DBP, NSE, and MBP levels in the two groups were higher than those before surgery, 1 h after anesthesia, and at the end of surgery, and the differences were statistically significant (P<0.05). Conclusion: Propofol combined with remifentanil can effectively improve the hemodynamic level of patients with emergency craniocerebral injury and protect their brain cell function, which is beneficial to the patient's prognosis and is worthy of clinical application.
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2020, Vol. 26 
