血清S-CD105 VEGF MMP9表达与非小细胞肺癌根治术后再复发的关系

doi:10.3969/j.issn.1006-6233.2020.08.012

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Abstract Objective: To investigate the relationship between the expression of serum soluble CD105 (S-CD105), vascular endothelial growth factor (VEGF), matrix metalloproteinase 9 (MMP9) and recurrence of non-small cell lung cancer (NSCLC) after radical operation. Methods: 102 patients with NSCLC treated in our hospital from September 2014 to October 2017 were selected as the study subjects, who were followed up for 2 years. They were divided into recurrence group (n=44) and non-recurrence group (n=52) based on the recurrence. Another 60 healthy persons were selected as the control group during the same period. The levels of serum S-CD105, VEGF and MMP9 were detected by ELISA, the changes of levels of serum S-CD105, VEGF and MMP9 were observed, the recurrence rates of patients with different levels of S-CD105, VEGF, MMP9S-CD105, VEGF and MMP9 were observed, and the predictive value of the expression of three factors for recurrence after NSCLC and the influencing factors were analyzed. Results: The levels of serum S-CD105, VEGF and MMP9 in the relapsed group were significantly higher than those in the non-relapsed group and the control group (P<0.05). The recurrence rate of patients with high expressions of serum S-CD105, VEGF and MMP9 was higher than that of patients with low expressions (P<0.05). MMP9 had the highest specificity but lower sensitivity in predicting recurrence of NSCLC, and AUC predicted by VEGF was the highest, and the sensitivity and specificity were slightly higher than those predicted by S-CD105. TNM stage, chemotherapy cycle, S-CD105, VEGF and MMP9 were independent risk factors for recurrence of NSCLC. Conclusion: Serum S-CD105, VEGF and MMP9 are highly expressed in patients with recurrent NSCLC, postoperative recurrence rate of patients with high expressions of the three factors is high. These three factors have certain predictive values for postoperative recurrence and are independent risk factors for postoperative recurrence.

Key words： Non-small cell lung cancer Radical resection Recurrence Soluble CD105 Vascular endothelial growth factor Matrix metalloproteinase 9

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.08.012 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I8/1281

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