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| Relationship between Levels of CRP cTnT TSLP miR-30c-5p and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris |
| HUANG Yubing, LIAO Wang, WANG Miao, et al |
| People's Hospital of Hainan Province /Hainan Hospital Affiliated to Hainan Medical College, Hainan Haikou 570311, China |
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Abstract Objective: To investigate the relationship between the levels of C-reactive protein (CRP), serum troponin T (cTnT), thymic stromal lymphopoietin (TSLP), miR-30c-5p and the severity of coronary artery disease in patients with stable angina pectoris (SAP). Methods: The clinical data of 90 SAP patients confirmed by coronary angiography (CAG) admitted to the hospital from May 2016 to May 2019 were retrospectively analyzed. They were divided into mild groups according to SYNTAX score (0~22 points, 41 cases). , Moderate group (23~32 points, 32 cases), Severe group (≥33 points, 17 cases). Collect clinical data of three groups of patients, collect blood to measure the CRP, cTnT, TSLP, miR-30c-5p levels of the three groups of patients. The severity of coronary artery disease in the three groups of patients was evaluated by SYNTAX score, and CRP, cTnT, Relationship between TSLP, miR-30c-5p levels and SYNTAX score. Results: The CRP, cTnT, TSLP, miR-30c-5p levels, and SYNTAX scores of the three groups of patients were statistically significant (P all<0.05). Pairwise comparisons of LSD-t tests showed statistically significant differences (P all<0.05). Pearson correlation analysis showed that CRP, cTnT, TSLP and SYNTAX scores were significantly positively correlated (P<0.01), while miR-30c-5p was significantly negatively correlated with SYNTAX scores (P<0.01). Conclusion: CRP, cTnT, TSLP, miR-30c-5p levels correlate with the severity of coronary artery disease in patients with stable angina pectoris. Early detection of the above biological markers can help determine the severity of coronary artery disease in patients with stable angina pectoris.
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2020, Vol. 26 
