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| Research on the Relevance Between Expressions of ER and PR and Postoperative Recurrence of Uterine Fibroids |
| XU Xu |
| The Sixth Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830002, China |
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Abstract Objective: To study the relationship between the expressions of estrogen receptor (ER) and progesterone receptor (PR) and postoperative recurrence in patients with uterine fibroids. Methods: 92 cases of patients with uterine fibroids admitted to our hospital were included in the study. 50 patients who underwent initial surgery were included in initial surgery group, and 42 patients who underwent surgery due to recurrence of fibroids were included into recurrent surgery group, and the expressions of ER and PR in fibroids tissues and adjacent tissues were compared between the two groups. According to the quantity of recurrent fibroids, 42 patients with recurrent surgery were divided into mono-recurrence group and multi-recurrence group, and the expressions of ER and PR in fibroids tissues were compared. Logsitic analysis was used to analyze the relationship between expression levels of ER and PR and postoperative recurrence in uterine fibroids tissues. Results: The positive rates of ER and PR in fibroids tissues in initial surgery group and recurrent surgery group were significantly higher than those in adjacent tissues (P<0.05), and the positive rates of ER and PR in recurrent surgery group were significantly higher than those in initial surgery group (P<0.05). The positive cell counts of ER and PR in fibroids tissues in multi-recurrence group were significantly higher than those in mono-recurrence group (P<0.05). Logistic analysis suggested that the high expressions of ER and PR in fibroids tissues were independent risk factors for postoperative recurrence in patients with uterine fibroids. Conclusions: The expression levels of ER and PR in fibroids tissues of patients with uterine fibroids are higher than those in adjacent tissues. The levels of ER and PR in fibroids tissues of recurrent patients are higher than those of patients with initial surgery, the more the recurrent fibroids, the higher the levels of ER and PR in fibroids tissues. The high expressions of ER and PR in tumor tissues are independent risk factors for postoperative recurrence in patients with uterine fibroids.
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2020, Vol. 26 
