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| Research on the Effect of Ultrasound-guided Peripheral Nerve Block Anesthesia on Cognitive Function Stress Response and Outcome in Elderly Patients Undergoing Hip Replacement |
| ZHONG Changyun, ZHAO Tianlan |
| Mianyang People's Hospital, Sichuan Mianyang 621000, China |
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Abstract Objective: To analyze the effect of ultrasound-guided peripheral nerve block anesthesia on cognitive function, stress response and postoperative outcome in elderly patients undergoing hip replacement. Methods: 92 patients undergoing hip replacement in our hospital were randomly divided into control group and experimental group, 46 cases in each group. The control group was given general anesthesia, and the experimental group was given peripheral nerve block anesthesia under the guidance of ultrasound. The cognitive function of patients after operation was investigated by MMSE. The changes of interleukin-6 (IL-6) and cortisol (COR) levels at different stages were observed to evaluate the stress response. The outcome was evaluated by the dosage of intravenous controlled analgesia (PCIA), the time of getting out of bed, the time of extubation and the length of hospital stay. The adverse symptoms after operation were investigated. Results: The results showed that the MMSE scores of the experimental group was higher than those of the control group at 6 hours and 1 day after operation, and the difference was significant (P<0.05); the dosage of PCIA, time of getting out of bed, time of extubation and length of hospital stay in the experimental group was lower than those in the control group, and the difference was significant (P<0.05); the levels of IL-6 and COR in the first and fourth stages was lower than those in the control group, and the difference was significant(P<0.05); the incidence of adverse symptoms such as headache, vomiting and urinary retention in the experimental group was not significantly different from those in the control group (P>0.05). Conclusion: Ultrasound-guided peripheral nerve block anesthesia has little influence on cognitive function of elderly hip replacement patients, reduces stress response, avoids adverse symptoms, speeds up the outcome of surgery, has obvious analgesic effect and high application value.
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2020, Vol. 26 
