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| Effects of Sequential Chemoradiotherapy on Curative Effect of Postoperative Adjuvant Therapy for Patients with Advanced Endometrial Cancer and Levels of Serum HE4 CA125 |
| GUO Wei, DIAO Haidan |
| Dalian Third People's Hospital, Liaoning Dalian 116033, China |
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Abstract Objective: To explore effects of sequential chemoradiotherapy on curative effect of postoperative adjuvant therapy for patients with advanced endometrial cancer (EC) and levels of serum HE4, CA125. Methods: The clinical data of 80 patients with advanced endometrial cancer from October 2015 to October 2017 were analyzed retrospectively, According to different treatment methods, they were divided into control group (n=40) and observation group (n=40). The control group was given routine adjuvant chemoradiotherapy, while observation group was given sequential chemoradiotherapy. The clinical curative effect, serum carbohydrate antigen 125 (CA125), human epididymis protein (HE4), incidence of complications, tumor metastasis rate, survival rate and survival time were compared between the two groups. Results: After treatment, total response rate of observation group was higher than that of control group (P<0.05). After treatment, levels of serum HE4 and CA125 in observation group were lower than those in control group (P<0.05). The incidence of complications in observation group was lower than that in control group (P<0.05). The tumor metastasis rate in observation group was lower than that in control group (P<0.05).The patients were followed up for 2 year. The 2-year survival rate of observation group was higher than that of control group, and survival time was better than that of control group (P<0.05). Conclusion: The effects of sequential chemoradiotherapy are good on curative effect of postoperative adjuvant therapy for patients with advanced EC. It can reduce levels of serum HE4 and CA125 level, reduce incidence of complications and tumor metastasis rate, and improve quality of life.
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2020, Vol. 26 
