|
|
|
| The Effect of Pramiphene Eye Drops on Corneal Endothelium and Lacrimal Inflammatory Index During Cataract Surgery Perioperative Period |
| ZHANG Juanjuan, XUE Tao, WANG Sheng, et al |
| The First People's Hospital of Xianyang, Shaanxi Xianyang 712000, China |
|
|
|
|
Abstract Objective: To observe the effect of Pramiphene eye drops on the corneal endothelium and lacrimal inflammatory index during cataract surgery perioperative period. Methods: Totally 580 cases (610 eyes) of cataract patients in our hospital, from January 2018 to September 2019, were randomly divided into two groups. Levofloxacin Eye Drops and Tobramycin & Dexamethasone Eye Drops were administrated to the control group (290 cases (302 eyes). On the basis of control group treatment, Pramiphene Eye Drops was administrated to the observation group (290 cases, 308 eyes). The corneal endothelium and lacrimal inflammation indexes were compared between the two groups. Results: There was no significant difference between the observation group and the control group in the loss rate of corneal endothelial cells at 1 week, 1 month and 3 months after operation (P > 0.05); there was no difference between the two groups in the index of lacrimal inflammatory factor IL-6 before operation, and the index of TNF in the observation group was significantly lower than that in the control group (P < 0.05). The difference was statistically significant (P < 0.05). Conclusion: The administration of Pramiphene Eye Drops in the perioperative period of cataract surgery does not increase the loss rate of corneal endothelial cells, which is beneficial to reducing the level of lacrimal inflammatory factors, and is worthy of clinical reference.
|
|
|
|
|
|
[1] 赵静,陈伟伟,金忠平.普拉洛芬联合0.3%玻璃酸钠滴眼液治疗白内障术后干眼症的疗效分析[J].中国基层医药,2019,26(24):3011~3014.
[2] 李冬梅,余素英,何苗,等.普拉洛芬滴眼液对白内障手术患者视网膜结构及外周血VEGF表达的影响[J].国际眼科杂志,2019,19(12):2031~2035.
[3] 范伟杰,赵峰.普拉洛芬联合玻璃酸钠滴眼液治疗白内障超声乳化术后干眼疗效观察[J].中国药业,2018,27(21):64~66.
[4] 韩彦来.普拉洛芬眼液应用于白内障术后炎症的控制效果[J].中国医药指南,2019,21(15):148~149.
[5] 黄玉霞,张木强,陈金妮.普拉洛芬联合玻璃酸钠治疗白内障术后干眼症的临床观察及并发症率分析[J].现代诊断与治疗,2019,25(10):174~176.
[6] 邱煜焱,康刚劲,李茂娇,等.白内障超声乳化术后泪膜变化与视觉质量相关性的早期研究[J].西南医科大学学报,2018,17(3):159~160. |
|
|
|
2020, Vol. 26 
