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| Levels and Clinical Significance of Serum Hs-CRP IL-6 TNF-α and PCT in Pregnant Women with Premature Rupture of Membranes |
| HUANG Hui, CHEN Liyuan, WANG Han |
| Wuhan First Hospital, Hubei Wuhan 430000, China |
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Abstract Objective:To explore levels and the clinical significance of serum hs-CRP, IL-6, TNF-α and PCT in pregnant women with premature rupture of membranes (PROM). Methods:During the period from January 2018 to June 2019, 38 pregnant women with PROM and intrauterine infection who were admitted to obstetrics and gynecology department of the hospital were enrolled as infection group. 54 pregnant women with PROM and without intrauterine infection were enrolled as non-infection group. 60 healthy pregnant women who underwent production inspection and delivery during the same period in the hospital were enrolled as control group. The fasting elbow venous blood in the morning of the three groups was collected. The levels of serum hs-CRP, IL-6, TNF-α and PCT were detected by enzyme-linked immunosorbent assay. Results:The levels of serum hs-CRP, IL-6, TNF-α and PCT were the highest in infection group, followed by non-infection group and control group (P<0.05). The levels of serum hs-CRP, IL-6, TNF-α and PCT of full-term and incomplete pregnant women in infection group were higher than those in non-infection group. The levels of serum hs-CRP, IL-6, TNF-α and PCT of incomplete pregnant women were higher than those of full-term pregnant women in infection group and non-infection group (P<0.05). In infection group, levels of serum hs-CRP, IL-6, TNF-α and PCT were the highest in pregnant women with severe infection, followed by moderate infection and mild infection (P<0.05). ROC curve analysis showed that serum hs-CRP, IL-6, TNF-α and PCT levels were of relatively higher diagnostic value for predicting intrauterine infection of PROM pregnant women. AUC of their combined prediction was the largest. The sensitivity and specificity were 90.6% and 92.7%, respectively. Conclusion:The combined detection with serum hs-CRP, IL-6, TNF-α and PCT levels is of positive predictive value for early intrauterine infection in pregnant women with PROM.
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2020, Vol. 26 
